Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome

A series of benzo[d]imidazole analogues of thiabenzole were synthesized and their anti-inflammatory activities toward NLRP3 (nucleotide-binding domain leucine-rich repeat containing protein family, pyrin domain-containing 3, also known as cryopyrin or NALP3) inflammasome were evaluated in vitro. Two...

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Detalles Bibliográficos
Autores principales: Pan, Liangkun, Hang, Nan, Zhang, Chao, Chen, Yu, Li, Shuchun, Sun, Yang, Li, Zhongjun, Meng, Xiangbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155809/
https://www.ncbi.nlm.nih.gov/pubmed/28146092
http://dx.doi.org/10.3390/molecules22020213

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