Cargando…

Synthesis, Anti-Breast Cancer Activity, and Molecular Docking Study of a New Group of Acetylenic Quinolinesulfonamide Derivatives

In this study, a series of regioisomeric acetylenic sulfamoylquinolines are designed, synthesized, and tested in vitro for their antiproliferative activity against three human breast cacer cell lines (T47D, MCF-7, and MDA-MB-231) and a human normal fibroblast (HFF-1) by 4-[3-(4-iodophenyl)-2-(4-nitr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marciniec, Krzysztof, Pawełczak, Bartosz, Latocha, Małgorzata, Skrzypek, Leszek, Maciążek-Jurczyk, Małgorzata, Boryczka, Stanisław
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155812/ https://www.ncbi.nlm.nih.gov/pubmed/28212337 http://dx.doi.org/10.3390/molecules22020300

Ejemplares similares

Characteristics of the Protoporphyrin IX Binding Sites on Human Serum Albumin Using Molecular Docking
por: Sułkowski, Leszek, et al.
Publicado: (2016)

Molecular Structure, In Vitro Anticancer Study and Molecular Docking of New Phosphate Derivatives of Betulin
por: Chrobak, Elwira, et al.
Publicado: (2021)

Design, Synthesis and Biological Evaluation of Quinoline-8-Sulfonamides as Inhibitors of the Tumor Cell-Specific M2 Isoform of Pyruvate Kinase: Preliminary Study
por: Marciniec, Krzysztof, et al.
Publicado: (2023)

Spectroscopic Studies on the Molecular Ageing of Serum Albumin
por: Chudzik, Mariola, et al.
Publicado: (2016)

Phosphate Derivatives of 3-Carboxyacylbetulin: SynThesis, In Vitro Anti-HIV and Molecular Docking Study
por: Marciniec, Krzysztof, et al.
Publicado: (2020)

New acetylenic derivatives of betulin and betulone, synthesis and cytotoxic activity
por: Bębenek, Ewa, et al.
Publicado: (2016)

Synthesis, Structure and Cytotoxic Activity of New Acetylenic Derivatives of Betulin
por: Boryczka, Stanisław, et al.
Publicado: (2013)

New Phosphorus Analogs of Bevirimat: Synthesis, Evaluation of Anti-HIV-1 Activity and Molecular Docking Study
por: Chrobak, Elwira, et al.
Publicado: (2019)

Alkoxy and Enediyne Derivatives Containing 1,4-Benzoquinone Subunits—Synthesis and Antitumor Activity
por: Kadela-Tomanek, Monika, et al.
Publicado: (2017)

The application of in silico experimental model in the assessment of ciprofloxacin and levofloxacin interaction with main SARS-CoV-2 targets: S-, E- and TMPRSS2 proteins, RNA-dependent RNA polymerase and papain-like protease (PLpro)—preliminary molecular docking analysis
por: Marciniec, Krzysztof, et al.
Publicado: (2021)

Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-Quinone
por: Kadela-Tomanek, Monika, et al.
Publicado: (2021)

Synthesis, Structure and Cytotoxic Activity of Mono- and Dialkoxy Derivatives of 5,8-Quinolinedione
por: Kadela, Monika, et al.
Publicado: (2016)

Betulin Phosphonates; Synthesis, Structure, and Cytotoxic Activity
por: Chrobak, Elwira, et al.
Publicado: (2016)

Novel triazoles of 3-acetylbetulin and betulone as anticancer agents
por: Bębenek, Ewa, et al.
Publicado: (2018)

Influence of Piracetam on Gliclazide—Glycated Human Serum Albumin Interaction. A Spectrofluorometric Study
por: Szkudlarek, Agnieszka, et al.
Publicado: (2018)

In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid
por: Szkudlarek, Agnieszka, et al.
Publicado: (2020)

Ciprofloxacin and moxifloxacin could interact with SARS-CoV-2 protease: preliminary in silico analysis
por: Marciniec, Krzysztof, et al.
Publicado: (2020)

Novel Triazole Hybrids of Betulin: Synthesis and Biological Activity Profile
por: Bębenek, Ewa, et al.
Publicado: (2017)

Hybrids of 1,4-Quinone with Quinoline Derivatives: Synthesis, Biological Activity, and Molecular Docking with DT-Diaphorase (NQO1)
por: Kadela-Tomanek, Monika, et al.
Publicado: (2022)

New Synthetic Quinoline (Qui) Derivatives as Novel Antioxidants and Potential HSA’s Antioxidant Activity Modulators—Spectroscopic Studies
por: Rogóż, Wojciech, et al.
Publicado: (2022)

Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines
por: Król, Sylwia K., et al.
Publicado: (2021)

Biological Activity and In Silico Study of 3-Modified Derivatives of Betulin and Betulinic Aldehyde
por: Bębenek, Ewa, et al.
Publicado: (2019)

Interaction between moxifloxacin and Mcl-1 and MITF proteins: the effect on growth inhibition and apoptosis in MDA-MB-231 human triple-negative breast cancer cells
por: Beberok, Artur, et al.
Publicado: (2022)

Synthesis and anticancer activity of multisubstituted purines and xanthines with one or two propynylthio and aminobutynylthio groups
por: Kowalska, Alicja, et al.
Publicado: (2018)

Anticancer Activity of the Acetylenic Derivative of Betulin Phosphate Involves Induction of Necrotic-Like Death in Breast Cancer Cells In Vitro
por: Orchel, Arkadiusz, et al.
Publicado: (2021)

Pre-Formulation Studies: Physicochemical Characteristics and In Vitro Release Kinetics of Insulin from Selected Hydrogels †
por: Ostróżka-Cieślik, Aneta, et al.
Publicado: (2021)

Spectroscopic Studies of Quinobenzothiazine Derivative in Terms of the In Vitro Interaction with Selected Human Plasma Proteins: Part 2
por: Owczarzy, Aleksandra, et al.
Publicado: (2023)

In Vitro Investigation of the Interaction of Tolbutamide and Losartan with Human Serum Albumin in Hyperglycemia States
por: Szkudlarek, Agnieszka, et al.
Publicado: (2017)

Effect of Temperature on Tolbutamide Binding to Glycated Serum Albumin
por: Szkudlarek, Agnieszka, et al.
Publicado: (2017)

Comparison of Losartan and Furosemide Interaction with HSA and Their Influence on HSA Antioxidant Potential
por: Rogóż, Wojciech, et al.
Publicado: (2022)

Circular Dichroism as a Rapid Method for Analyzing the Binding of a Targeting Ligand to the Surface of Albumin Nanoparticles
por: Kulig, Karolina, et al.
Publicado: (2023)

Spectroscopic Studies of Quinobenzothiazine Derivative in Terms of the In Vitro Interaction with Selected Human Plasma Proteins. Part 1
por: Owczarzy, Aleksandra, et al.
Publicado: (2021)

Changes in Glycated Human Serum Albumin Binding Affinity for Losartan in the Presence of Fatty Acids In Vitro Spectroscopic Analysis
por: Szkudlarek, Agnieszka, et al.
Publicado: (2022)

The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
por: Rogóż, Wojciech, et al.
Publicado: (2023)

Synthesis of dehydrodipeptide esters and their evaluation as inhibitors of cathepsin C
por: Makowski, Maciej, et al.
Publicado: (2015)

Synthesis of “Acetylene-Expanded” Tridentate Ligands
por: Holmes, Brian T., et al.
Publicado: (2002)

Synthesis and in vitro antiproliferative activity of novel 12(H)-quino[3,4-b][1,4]benzothiazine derivatives
por: Zięba, Andrzej, et al.
Publicado: (2012)

Synthesis and anticancer activity of thiosubstituted purines
por: Kowalska, Alicja, et al.
Publicado: (2015)

Human Serum Albumin Aggregation/Fibrillation and its Abilities to Drugs Binding
por: Maciążek-Jurczyk, Małgorzata, et al.
Publicado: (2020)

Spectroscopic Analysis of an Antimalarial Drug’s (Quinine) Influence on Human Serum Albumin Reduction and Antioxidant Potential
por: Rogóż, Wojciech, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h7ghrnvmtpq94asts38mlgfqks