Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders

A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction an...

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Autores principales: Fasching, Patrizia, Stradner, Martin, Graninger, Winfried, Dejaco, Christian, Fessler, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155880/
https://www.ncbi.nlm.nih.gov/pubmed/28098832
http://dx.doi.org/10.3390/molecules22010134
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author Fasching, Patrizia
Stradner, Martin
Graninger, Winfried
Dejaco, Christian
Fessler, Johannes
author_facet Fasching, Patrizia
Stradner, Martin
Graninger, Winfried
Dejaco, Christian
Fessler, Johannes
author_sort Fasching, Patrizia
collection PubMed
description A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the  pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims to summarize recent data and advances in targeted therapeutic modification of the Th17/Treg-balance, as well as information on the efficacy of candidate therapeutics with respect to the treatment of autoimmune diseases.
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spelling pubmed-61558802018-11-13 Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders Fasching, Patrizia Stradner, Martin Graninger, Winfried Dejaco, Christian Fessler, Johannes Molecules Review A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the  pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims to summarize recent data and advances in targeted therapeutic modification of the Th17/Treg-balance, as well as information on the efficacy of candidate therapeutics with respect to the treatment of autoimmune diseases. MDPI 2017-01-14 /pmc/articles/PMC6155880/ /pubmed/28098832 http://dx.doi.org/10.3390/molecules22010134 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fasching, Patrizia
Stradner, Martin
Graninger, Winfried
Dejaco, Christian
Fessler, Johannes
Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
title Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
title_full Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
title_fullStr Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
title_full_unstemmed Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
title_short Therapeutic Potential of Targeting the Th17/Treg Axis in Autoimmune Disorders
title_sort therapeutic potential of targeting the th17/treg axis in autoimmune disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155880/
https://www.ncbi.nlm.nih.gov/pubmed/28098832
http://dx.doi.org/10.3390/molecules22010134
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