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Bioactive Nutrients and Nutrigenomics in Age-Related Diseases

The increased life expectancy and the expansion of the elderly population are stimulating research into aging. Aging may be viewed as a multifactorial process that results from the interaction of genetic and environmental factors, which include lifestyle. Human molecular processes are influenced by...

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Autores principales: Rescigno, Tania, Micolucci, Luigina, Tecce, Mario F., Capasso, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155887/
https://www.ncbi.nlm.nih.gov/pubmed/28075340
http://dx.doi.org/10.3390/molecules22010105
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author Rescigno, Tania
Micolucci, Luigina
Tecce, Mario F.
Capasso, Anna
author_facet Rescigno, Tania
Micolucci, Luigina
Tecce, Mario F.
Capasso, Anna
author_sort Rescigno, Tania
collection PubMed
description The increased life expectancy and the expansion of the elderly population are stimulating research into aging. Aging may be viewed as a multifactorial process that results from the interaction of genetic and environmental factors, which include lifestyle. Human molecular processes are influenced by physiological pathways as well as exogenous factors, which include the diet. Dietary components have substantive effects on metabolic health; for instance, bioactive molecules capable of selectively modulating specific metabolic pathways affect the development/progression of cardiovascular and neoplastic disease. As bioactive nutrients are increasingly identified, their clinical and molecular chemopreventive effects are being characterized and systematic analyses encompassing the “omics” technologies (transcriptomics, proteomics and metabolomics) are being conducted to explore their action. The evolving field of molecular pathological epidemiology has unique strength to investigate the effects of dietary and lifestyle exposure on clinical outcomes. The mounting body of knowledge regarding diet-related health status and disease risk is expected to lead in the near future to the development of improved diagnostic procedures and therapeutic strategies targeting processes relevant to nutrition. The state of the art of aging and nutrigenomics research and the molecular mechanisms underlying the beneficial effects of bioactive nutrients on the main aging-related disorders are reviewed herein.
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spelling pubmed-61558872018-11-13 Bioactive Nutrients and Nutrigenomics in Age-Related Diseases Rescigno, Tania Micolucci, Luigina Tecce, Mario F. Capasso, Anna Molecules Review The increased life expectancy and the expansion of the elderly population are stimulating research into aging. Aging may be viewed as a multifactorial process that results from the interaction of genetic and environmental factors, which include lifestyle. Human molecular processes are influenced by physiological pathways as well as exogenous factors, which include the diet. Dietary components have substantive effects on metabolic health; for instance, bioactive molecules capable of selectively modulating specific metabolic pathways affect the development/progression of cardiovascular and neoplastic disease. As bioactive nutrients are increasingly identified, their clinical and molecular chemopreventive effects are being characterized and systematic analyses encompassing the “omics” technologies (transcriptomics, proteomics and metabolomics) are being conducted to explore their action. The evolving field of molecular pathological epidemiology has unique strength to investigate the effects of dietary and lifestyle exposure on clinical outcomes. The mounting body of knowledge regarding diet-related health status and disease risk is expected to lead in the near future to the development of improved diagnostic procedures and therapeutic strategies targeting processes relevant to nutrition. The state of the art of aging and nutrigenomics research and the molecular mechanisms underlying the beneficial effects of bioactive nutrients on the main aging-related disorders are reviewed herein. MDPI 2017-01-08 /pmc/articles/PMC6155887/ /pubmed/28075340 http://dx.doi.org/10.3390/molecules22010105 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rescigno, Tania
Micolucci, Luigina
Tecce, Mario F.
Capasso, Anna
Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
title Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
title_full Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
title_fullStr Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
title_full_unstemmed Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
title_short Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
title_sort bioactive nutrients and nutrigenomics in age-related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155887/
https://www.ncbi.nlm.nih.gov/pubmed/28075340
http://dx.doi.org/10.3390/molecules22010105
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