Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-ray Diffraction

A new schiartane-type nortriterpenoid, micrandilactone H was isolated from Kadsura longipedunculata Finet et Gagnep. Its 2D (two dimension) structure was elucidated by NMR spectroscopic analysis, and it is similar to that of Kadnanolactones H and the absolute configuration was established through X-...

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Autores principales: Wang, Xiaojuan, Fronczek, Frank R., Chen, Jiabao, Liu, Jiabao, Ferreira, Daneel, Li, Shuai, Hamann, Mark T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155901/
https://www.ncbi.nlm.nih.gov/pubmed/28045449
http://dx.doi.org/10.3390/molecules22010065
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author Wang, Xiaojuan
Fronczek, Frank R.
Chen, Jiabao
Liu, Jiabao
Ferreira, Daneel
Li, Shuai
Hamann, Mark T.
author_facet Wang, Xiaojuan
Fronczek, Frank R.
Chen, Jiabao
Liu, Jiabao
Ferreira, Daneel
Li, Shuai
Hamann, Mark T.
author_sort Wang, Xiaojuan
collection PubMed
description A new schiartane-type nortriterpenoid, micrandilactone H was isolated from Kadsura longipedunculata Finet et Gagnep. Its 2D (two dimension) structure was elucidated by NMR spectroscopic analysis, and it is similar to that of Kadnanolactones H and the absolute configuration was established through X-ray diffraction and ECD data analysis. This represents the first complete assignment of the absolute configuration of a schiartane-type nortriterpenoid by X-ray diffraction and the ECD method. Micrandilactone H showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 56.84% at 10 μM.
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spelling pubmed-61559012018-11-13 Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-ray Diffraction Wang, Xiaojuan Fronczek, Frank R. Chen, Jiabao Liu, Jiabao Ferreira, Daneel Li, Shuai Hamann, Mark T. Molecules Article A new schiartane-type nortriterpenoid, micrandilactone H was isolated from Kadsura longipedunculata Finet et Gagnep. Its 2D (two dimension) structure was elucidated by NMR spectroscopic analysis, and it is similar to that of Kadnanolactones H and the absolute configuration was established through X-ray diffraction and ECD data analysis. This represents the first complete assignment of the absolute configuration of a schiartane-type nortriterpenoid by X-ray diffraction and the ECD method. Micrandilactone H showed moderate hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced toxicity in HepG2 cells with cell survival rates of 56.84% at 10 μM. MDPI 2017-01-02 /pmc/articles/PMC6155901/ /pubmed/28045449 http://dx.doi.org/10.3390/molecules22010065 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Xiaojuan
Fronczek, Frank R.
Chen, Jiabao
Liu, Jiabao
Ferreira, Daneel
Li, Shuai
Hamann, Mark T.
Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-ray Diffraction
title Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-ray Diffraction
title_full Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-ray Diffraction
title_fullStr Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-ray Diffraction
title_full_unstemmed Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-ray Diffraction
title_short Assignment of Absolute Configuration of a New Hepatoprotective Schiartane-Type Nortriterpenoid Using X-ray Diffraction
title_sort assignment of absolute configuration of a new hepatoprotective schiartane-type nortriterpenoid using x-ray diffraction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155901/
https://www.ncbi.nlm.nih.gov/pubmed/28045449
http://dx.doi.org/10.3390/molecules22010065
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