Comparison of (99m)Tc-methyl diphosphonate bone scintigraphy and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma

We compared the usefulness of (99m)Tc-methyl diphosphonate ((99m)Tc-MDP) bone scintigraphy and (18)F-fluorodeoxyglucose (FDG) for positron emission tomography/computed tomography (PET/CT) in predicting histologic response in patients with osteosarcoma receiving neoadjuvant chemotherapy (NAC). We ret...

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Autores principales: Lee, Inki, Byun, Byung Hyun, Lim, Ilhan, Kim, Byung Il, Kong, Chang-Bae, Song, Won Seok, Cho, Wan Hyeong, Koh, Jae-Soo, Lim, Sang Moo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155965/
https://www.ncbi.nlm.nih.gov/pubmed/30212975
http://dx.doi.org/10.1097/MD.0000000000012318
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author Lee, Inki
Byun, Byung Hyun
Lim, Ilhan
Kim, Byung Il
Kong, Chang-Bae
Song, Won Seok
Cho, Wan Hyeong
Koh, Jae-Soo
Lim, Sang Moo
author_facet Lee, Inki
Byun, Byung Hyun
Lim, Ilhan
Kim, Byung Il
Kong, Chang-Bae
Song, Won Seok
Cho, Wan Hyeong
Koh, Jae-Soo
Lim, Sang Moo
author_sort Lee, Inki
collection PubMed
description We compared the usefulness of (99m)Tc-methyl diphosphonate ((99m)Tc-MDP) bone scintigraphy and (18)F-fluorodeoxyglucose (FDG) for positron emission tomography/computed tomography (PET/CT) in predicting histologic response in patients with osteosarcoma receiving neoadjuvant chemotherapy (NAC). We retrospectively reviewed 62 patients with high-grade osteosarcoma who had received 2 cycles of NAC and surgery. All patients underwent (99m)Tc-MDP bone scintigraphy and (18)F-FDG PET/CT before and after NAC. (99m)Tc-MDP uptake in the primary tumor was measured quantitatively as the maximum tumor-to-nontumor ratio (T/NT(max)) and (18)F-FDG uptake was measured as the maximum standardized uptake value (SUV(max)), before and after NAC. The percent changes of T/NT(max) (percent changes of the maximum tumor-to-nontumor ratio [Δ%T/NT(max)]) and SUV(max) (percent changes of the maximum standardized uptake value [Δ%SUV(max)]) after NAC were calculated and the correlations between these parameters were evaluated. After surgery, the effects of NAC were graded histopathologically (good vs poor) and the optimum cut-off values of Δ%T/NT(max) and Δ%SUV(max) for predicting histologic response were assessed using the receiver operating characteristic (ROC) curve analysis. Δ%T/NT(max) and Δ%SUV(max) were positively correlated with each other (r = 0.494, P < .01). Based on the ROC curve analysis, both Δ%T/NT(max) (area under the curve [AUC] = .772, P < .01) and Δ%SUV(max) (AUC = .829, P < .01) predicted good histologic response. However, there was no significant difference between the AUCs of Δ%T/NT(max) and Δ%SUV(max) (P = .44). The sensitivity and specificity for predicting good histologic response were 83.3% and 75.0%, for the criterion Δ%T/NT(max) <–12.5%, and 80.0% and 81.3% for the criterion Δ%SUV(max) <−49.0%, respectively. The (99m)Tc-MDP bone scan and (18)F-FDG PET scan are non-inferior to each other in predicting the histologic response of osteosarcoma treatments. The (99m)Tc-MDP bone scan and (18)F-FDG PET scan showed respective advantages with differing features. Therefore, physicians should consider which scan is appropriate for their own institute based on the advantages of each scan and the circumstances of the institute.
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spelling pubmed-61559652018-11-08 Comparison of (99m)Tc-methyl diphosphonate bone scintigraphy and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma Lee, Inki Byun, Byung Hyun Lim, Ilhan Kim, Byung Il Kong, Chang-Bae Song, Won Seok Cho, Wan Hyeong Koh, Jae-Soo Lim, Sang Moo Medicine (Baltimore) Research Article We compared the usefulness of (99m)Tc-methyl diphosphonate ((99m)Tc-MDP) bone scintigraphy and (18)F-fluorodeoxyglucose (FDG) for positron emission tomography/computed tomography (PET/CT) in predicting histologic response in patients with osteosarcoma receiving neoadjuvant chemotherapy (NAC). We retrospectively reviewed 62 patients with high-grade osteosarcoma who had received 2 cycles of NAC and surgery. All patients underwent (99m)Tc-MDP bone scintigraphy and (18)F-FDG PET/CT before and after NAC. (99m)Tc-MDP uptake in the primary tumor was measured quantitatively as the maximum tumor-to-nontumor ratio (T/NT(max)) and (18)F-FDG uptake was measured as the maximum standardized uptake value (SUV(max)), before and after NAC. The percent changes of T/NT(max) (percent changes of the maximum tumor-to-nontumor ratio [Δ%T/NT(max)]) and SUV(max) (percent changes of the maximum standardized uptake value [Δ%SUV(max)]) after NAC were calculated and the correlations between these parameters were evaluated. After surgery, the effects of NAC were graded histopathologically (good vs poor) and the optimum cut-off values of Δ%T/NT(max) and Δ%SUV(max) for predicting histologic response were assessed using the receiver operating characteristic (ROC) curve analysis. Δ%T/NT(max) and Δ%SUV(max) were positively correlated with each other (r = 0.494, P < .01). Based on the ROC curve analysis, both Δ%T/NT(max) (area under the curve [AUC] = .772, P < .01) and Δ%SUV(max) (AUC = .829, P < .01) predicted good histologic response. However, there was no significant difference between the AUCs of Δ%T/NT(max) and Δ%SUV(max) (P = .44). The sensitivity and specificity for predicting good histologic response were 83.3% and 75.0%, for the criterion Δ%T/NT(max) <–12.5%, and 80.0% and 81.3% for the criterion Δ%SUV(max) <−49.0%, respectively. The (99m)Tc-MDP bone scan and (18)F-FDG PET scan are non-inferior to each other in predicting the histologic response of osteosarcoma treatments. The (99m)Tc-MDP bone scan and (18)F-FDG PET scan showed respective advantages with differing features. Therefore, physicians should consider which scan is appropriate for their own institute based on the advantages of each scan and the circumstances of the institute. Wolters Kluwer Health 2018-09-14 /pmc/articles/PMC6155965/ /pubmed/30212975 http://dx.doi.org/10.1097/MD.0000000000012318 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Research Article
Lee, Inki
Byun, Byung Hyun
Lim, Ilhan
Kim, Byung Il
Kong, Chang-Bae
Song, Won Seok
Cho, Wan Hyeong
Koh, Jae-Soo
Lim, Sang Moo
Comparison of (99m)Tc-methyl diphosphonate bone scintigraphy and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma
title Comparison of (99m)Tc-methyl diphosphonate bone scintigraphy and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma
title_full Comparison of (99m)Tc-methyl diphosphonate bone scintigraphy and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma
title_fullStr Comparison of (99m)Tc-methyl diphosphonate bone scintigraphy and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma
title_full_unstemmed Comparison of (99m)Tc-methyl diphosphonate bone scintigraphy and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma
title_short Comparison of (99m)Tc-methyl diphosphonate bone scintigraphy and (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma
title_sort comparison of (99m)tc-methyl diphosphonate bone scintigraphy and (18)f-fluorodeoxyglucose positron emission tomography/computed tomography to predict histologic response to neoadjuvant chemotherapy in patients with osteosarcoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155965/
https://www.ncbi.nlm.nih.gov/pubmed/30212975
http://dx.doi.org/10.1097/MD.0000000000012318
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