Cargando…

Unlocking a dark past

A transcription factor called SALL4 could be the missing link between thalidomide and the limb defects caused by the drug.

Detalles Bibliográficos
Autores principales:	Rodríguez-Pérez, Fernando, Rape, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156077/ https://www.ncbi.nlm.nih.gov/pubmed/30252647 http://dx.doi.org/10.7554/eLife.41002

Ejemplares similares

Multisite dependency of an E3 ligase controls monoubiquitylation-dependent cell fate decisions
por: Werner, Achim, et al.
Publicado: (2018)

Caught in the act
por: Meyer, Hermann-Josef, et al.
Publicado: (2013)

Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets
por: Rodriguez, Kelsie M, et al.
Publicado: (2021)

Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G(4)C(2) RNA in a cellular model
por: Frottin, Frédéric, et al.
Publicado: (2021)

Structure-based inhibitors of amyloid beta core suggest a common interface with tau
por: Griner, Sarah L, et al.
Publicado: (2019)

High-throughput proteomics of nanogram-scale samples with Zeno SWATH MS
por: Wang, Ziyue, et al.
Publicado: (2022)

Genetic analysis reveals functions of atypical polyubiquitin chains
por: Meza Gutierrez, Fernando, et al.
Publicado: (2018)

Tissue-specific targeting of DNA nanodevices in a multicellular living organism
por: Chakraborty, Kasturi, et al.
Publicado: (2021)

Multiple ciliary localization signals control INPP5E ciliary targeting
por: Cilleros-Rodriguez, Dario, et al.
Publicado: (2022)

Manganese is a physiologically relevant TORC1 activator in yeast and mammals
por: Nicastro, Raffaele, et al.
Publicado: (2022)

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
por: Ryan, Dylan Gerard, et al.
Publicado: (2021)

Structural basis for the activation of PLC-γ isozymes by phosphorylation and cancer-associated mutations
por: Hajicek, Nicole, et al.
Publicado: (2019)

Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate
por: Rodriguez Camargo, Diana C, et al.
Publicado: (2017)

Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production
por: Bongers, Mareike, et al.
Publicado: (2020)

DnaJC7 specifically regulates tau seeding
por: Perez, Valerie Ann, et al.
Publicado: (2023)

Comment on ‘YcgC represents a new protein deacetylase family in prokaryotes’
por: Kremer, Magdalena, et al.
Publicado: (2018)

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes
por: Siraliev-Perez, Edhriz, et al.
Publicado: (2022)

Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist
por: Glassman, Caleb R, et al.
Publicado: (2021)

Evolution of multifunctionality through a pleiotropic substitution in the innate immune protein S100A9
por: Harman, Joseph L, et al.
Publicado: (2020)

Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
por: Trinh, Michael Nguyen, et al.
Publicado: (2018)

Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library
por: Lite, Thuy-Lan V, et al.
Publicado: (2020)

Regulation of mRNA translation by a photoriboswitch
por: Rotstan, Kelly A, et al.
Publicado: (2020)

A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation
por: Boone, Morgane, et al.
Publicado: (2022)

Single molecule mechanics resolves the earliest events in force generation by cardiac myosin
por: Woody, Michael S, et al.
Publicado: (2019)

Homo-oligomerization of the human adenosine A(2A) receptor is driven by the intrinsically disordered C-terminus
por: Nguyen, Khanh Dinh Quoc, et al.
Publicado: (2021)

The conserved centrosomin motif, γTuNA, forms a dimer that directly activates microtubule nucleation by the γ-tubulin ring complex (γTuRC)
por: Rale, Michael J, et al.
Publicado: (2022)

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock
por: Azkanaz, Maria, et al.
Publicado: (2019)

Fatal amyloid formation in a patient’s antibody light chain is caused by a single point mutation
por: Kazman, Pamina, et al.
Publicado: (2020)

A new class of disordered elements controls DNA replication through initiator self-assembly
por: Parker, Matthew W, et al.
Publicado: (2019)

Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform
por: Siepe, Dirk H, et al.
Publicado: (2022)

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
por: Jain, Kanishk, et al.
Publicado: (2023)

From vesicle to cytosol
por: Rogers, Michael J, et al.
Publicado: (2018)

Amidst multiple binding orientations on fork DNA, Saccharolobus MCM helicase proceeds N-first for unwinding
por: Perera, Himasha M, et al.
Publicado: (2019)

LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex
por: Canny, Marella D, et al.
Publicado: (2022)

Spatially compartmentalized phase regulation of a Ca(2+)-cAMP-PKA oscillatory circuit
por: Tenner, Brian, et al.
Publicado: (2020)

The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains
por: Rodriguez Carvajal, Alan, et al.
Publicado: (2021)

Ctf4 organizes sister replisomes and Pol α into a replication factory
por: Yuan, Zuanning, et al.
Publicado: (2019)

Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil
por: Snoberger, Aaron, et al.
Publicado: (2021)

An explanation for origin unwinding in eukaryotes
por: Langston, Lance D, et al.
Publicado: (2019)

Getting ready for DNA duplication
por: Yao, Nina Y, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ngofm57os28stmr98rjpn8va6k