The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9

PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits PCSK9 into the secretory pathway, but its identity has remained elusive. Here, we apply a novel approach that combines prox...

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Detalles Bibliográficos
Autores principales: Emmer, Brian T, Hesketh, Geoffrey G, Kotnik, Emilee, Tang, Vi T, Lascuna, Paul J, Xiang, Jie, Gingras, Anne-Claude, Chen, Xiao-Wei, Ginsburg, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156083/
https://www.ncbi.nlm.nih.gov/pubmed/30251625
http://dx.doi.org/10.7554/eLife.38839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156083/
https://www.ncbi.nlm.nih.gov/pubmed/30251625
http://dx.doi.org/10.7554/eLife.38839

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