Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles

[Image: see text] The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation–growth mechanism in which large lignin molecules f...

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Autores principales: Sipponen, Mika H., Lange, Heiko, Ago, Mariko, Crestini, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156105/
https://www.ncbi.nlm.nih.gov/pubmed/30271691
http://dx.doi.org/10.1021/acssuschemeng.8b01652
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author Sipponen, Mika H.
Lange, Heiko
Ago, Mariko
Crestini, Claudia
author_facet Sipponen, Mika H.
Lange, Heiko
Ago, Mariko
Crestini, Claudia
author_sort Sipponen, Mika H.
collection PubMed
description [Image: see text] The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation–growth mechanism in which large lignin molecules formed the initial critical nuclei. Using this information, we demonstrate entrapment of budesonide in LNPs and subsequent pH-triggered and surfactant-responsive release of this synthetic anti-inflammatory corticosteroid. Overall, our results not only provide a promising intestinal delivery system for budesonide but also deliver fundamental mechanistic understanding for the entrapment of actives in LNPs with controlled size and release properties.
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spelling pubmed-61561052018-09-27 Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles Sipponen, Mika H. Lange, Heiko Ago, Mariko Crestini, Claudia ACS Sustain Chem Eng [Image: see text] The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation–growth mechanism in which large lignin molecules formed the initial critical nuclei. Using this information, we demonstrate entrapment of budesonide in LNPs and subsequent pH-triggered and surfactant-responsive release of this synthetic anti-inflammatory corticosteroid. Overall, our results not only provide a promising intestinal delivery system for budesonide but also deliver fundamental mechanistic understanding for the entrapment of actives in LNPs with controlled size and release properties. American Chemical Society 2018-05-25 2018-07-02 /pmc/articles/PMC6156105/ /pubmed/30271691 http://dx.doi.org/10.1021/acssuschemeng.8b01652 Text en Copyright © 2018 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Sipponen, Mika H.
Lange, Heiko
Ago, Mariko
Crestini, Claudia
Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles
title Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles
title_full Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles
title_fullStr Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles
title_full_unstemmed Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles
title_short Understanding Lignin Aggregation Processes. A Case Study: Budesonide Entrapment and Stimuli Controlled Release from Lignin Nanoparticles
title_sort understanding lignin aggregation processes. a case study: budesonide entrapment and stimuli controlled release from lignin nanoparticles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156105/
https://www.ncbi.nlm.nih.gov/pubmed/30271691
http://dx.doi.org/10.1021/acssuschemeng.8b01652
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