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A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study
PURPOSE: The primary aim of this study was to evaluate the effectiveness of a 6-month multicomponent intervention on physical function in socioeconomically vulnerable older adults in rural communities. As secondary aims, we evaluated the effectiveness of the intervention on frailty and other geriatr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156114/ https://www.ncbi.nlm.nih.gov/pubmed/30275687 http://dx.doi.org/10.2147/CIA.S177018 |
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author | Jang, Il-Young Jung, Hee-Won Park, Hyelim Lee, Chang Ki Yu, Sang Soo Lee, Young Soo Lee, Eunju Glynn, Robert J Kim, Dae Hyun |
author_facet | Jang, Il-Young Jung, Hee-Won Park, Hyelim Lee, Chang Ki Yu, Sang Soo Lee, Young Soo Lee, Eunju Glynn, Robert J Kim, Dae Hyun |
author_sort | Jang, Il-Young |
collection | PubMed |
description | PURPOSE: The primary aim of this study was to evaluate the effectiveness of a 6-month multicomponent intervention on physical function in socioeconomically vulnerable older adults in rural communities. As secondary aims, we evaluated the effectiveness of the intervention on frailty and other geriatric syndromes, sustained benefit at 12 months, and baseline characteristics associated with poor response. PATIENTS AND METHODS: This designed-delay study was conducted in 187 adults (mean age: 77 years; 75% women) who were living alone or on a low income in three rural regions of Korea. A 24-week multicomponent program that consisted of group exercise, nutritional supplementation, depression management, deprescribing medications, and home hazard reduction was implemented with a planned 6-month interval from August 2015 through January 2017. The primary outcome was physical function, measured using the Short Physical Performance Battery (SPPB) score (range: 0–12; minimum clinically important difference ≥1) at 6 months. Secondary outcomes included frailty phenotype, sarcopenia, Mini Nutritional Assessment-Short Form score (range: 0–14), Center for Epidemiologic Studies-Depression Scale score (range: 0–60), and falls. RESULTS: At 6 months, the SPPB score increased by 3.18 points (95% CI: 2.89, 3.48) from baseline. The program improved frailty (odds ratio: 0.06; 95% CI: 0.02, 0.16), sarcopenia (odds ratio: 0.32; 95% CI: 0.15, 0.68), Mini Nutritional Assessment-Short Form score by 1.67 points (95% CI: 1.28, 2.06), and Center for Epidemiologic Studies-Depression Scale score by −3.83 points (95% CI: −5.26, −2.39), except for fall (rate ratio: 0.99; 95% CI: 0.69, 1.43). These beneficial effects were sustained at 12 months. Body mass index ≥27 kg/m(2) and instrumental activities of daily living disability at baseline were associated with poor improvement in the SPPB score. CONCLUSION: This 24-week multicomponent program had sustained beneficial effects up to 1 year on physical function, frailty, sarcopenia, depressive symptoms, and nutritional status in socioeconomically vulnerable older adults in rural communities. (ClinicalTrials.gov, NCT 02554994) |
format | Online Article Text |
id | pubmed-6156114 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-61561142018-10-01 A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study Jang, Il-Young Jung, Hee-Won Park, Hyelim Lee, Chang Ki Yu, Sang Soo Lee, Young Soo Lee, Eunju Glynn, Robert J Kim, Dae Hyun Clin Interv Aging Original Research PURPOSE: The primary aim of this study was to evaluate the effectiveness of a 6-month multicomponent intervention on physical function in socioeconomically vulnerable older adults in rural communities. As secondary aims, we evaluated the effectiveness of the intervention on frailty and other geriatric syndromes, sustained benefit at 12 months, and baseline characteristics associated with poor response. PATIENTS AND METHODS: This designed-delay study was conducted in 187 adults (mean age: 77 years; 75% women) who were living alone or on a low income in three rural regions of Korea. A 24-week multicomponent program that consisted of group exercise, nutritional supplementation, depression management, deprescribing medications, and home hazard reduction was implemented with a planned 6-month interval from August 2015 through January 2017. The primary outcome was physical function, measured using the Short Physical Performance Battery (SPPB) score (range: 0–12; minimum clinically important difference ≥1) at 6 months. Secondary outcomes included frailty phenotype, sarcopenia, Mini Nutritional Assessment-Short Form score (range: 0–14), Center for Epidemiologic Studies-Depression Scale score (range: 0–60), and falls. RESULTS: At 6 months, the SPPB score increased by 3.18 points (95% CI: 2.89, 3.48) from baseline. The program improved frailty (odds ratio: 0.06; 95% CI: 0.02, 0.16), sarcopenia (odds ratio: 0.32; 95% CI: 0.15, 0.68), Mini Nutritional Assessment-Short Form score by 1.67 points (95% CI: 1.28, 2.06), and Center for Epidemiologic Studies-Depression Scale score by −3.83 points (95% CI: −5.26, −2.39), except for fall (rate ratio: 0.99; 95% CI: 0.69, 1.43). These beneficial effects were sustained at 12 months. Body mass index ≥27 kg/m(2) and instrumental activities of daily living disability at baseline were associated with poor improvement in the SPPB score. CONCLUSION: This 24-week multicomponent program had sustained beneficial effects up to 1 year on physical function, frailty, sarcopenia, depressive symptoms, and nutritional status in socioeconomically vulnerable older adults in rural communities. (ClinicalTrials.gov, NCT 02554994) Dove Medical Press 2018-09-19 /pmc/articles/PMC6156114/ /pubmed/30275687 http://dx.doi.org/10.2147/CIA.S177018 Text en © 2018 Jang et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Jang, Il-Young Jung, Hee-Won Park, Hyelim Lee, Chang Ki Yu, Sang Soo Lee, Young Soo Lee, Eunju Glynn, Robert J Kim, Dae Hyun A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study |
title | A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study |
title_full | A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study |
title_fullStr | A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study |
title_full_unstemmed | A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study |
title_short | A multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study |
title_sort | multicomponent frailty intervention for socioeconomically vulnerable older adults: a designed-delay study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156114/ https://www.ncbi.nlm.nih.gov/pubmed/30275687 http://dx.doi.org/10.2147/CIA.S177018 |
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