Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease

CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for...

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Autores principales: Bedsaul, Jacquelyn R., Carter, Nicole M., Deibel, Katelynn E., Hutcherson, Shelby M., Jones, Tyler A., Wang, Zhaoquan, Yang, Chao, Yang, Yong-Kang, Pomerantz, Joel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156143/
https://www.ncbi.nlm.nih.gov/pubmed/30283447
http://dx.doi.org/10.3389/fimmu.2018.02105
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author Bedsaul, Jacquelyn R.
Carter, Nicole M.
Deibel, Katelynn E.
Hutcherson, Shelby M.
Jones, Tyler A.
Wang, Zhaoquan
Yang, Chao
Yang, Yong-Kang
Pomerantz, Joel L.
author_facet Bedsaul, Jacquelyn R.
Carter, Nicole M.
Deibel, Katelynn E.
Hutcherson, Shelby M.
Jones, Tyler A.
Wang, Zhaoquan
Yang, Chao
Yang, Yong-Kang
Pomerantz, Joel L.
author_sort Bedsaul, Jacquelyn R.
collection PubMed
description CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for primary immunodeficiency. In this review, we summarize our current understanding of how CARD11 signals, how its activity is regulated, and how mutations bypass normal regulation to cause disease.
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spelling pubmed-61561432018-10-03 Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease Bedsaul, Jacquelyn R. Carter, Nicole M. Deibel, Katelynn E. Hutcherson, Shelby M. Jones, Tyler A. Wang, Zhaoquan Yang, Chao Yang, Yong-Kang Pomerantz, Joel L. Front Immunol Immunology CARD11 functions as a key signaling scaffold that controls antigen-induced lymphocyte activation during the adaptive immune response. Somatic mutations in CARD11 are frequently found in Non-Hodgkin lymphoma, and at least three classes of germline CARD11 mutations have been described as the basis for primary immunodeficiency. In this review, we summarize our current understanding of how CARD11 signals, how its activity is regulated, and how mutations bypass normal regulation to cause disease. Frontiers Media S.A. 2018-09-19 /pmc/articles/PMC6156143/ /pubmed/30283447 http://dx.doi.org/10.3389/fimmu.2018.02105 Text en Copyright © 2018 Bedsaul, Carter, Deibel, Hutcherson, Jones, Wang, Yang, Yang and Pomerantz. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Bedsaul, Jacquelyn R.
Carter, Nicole M.
Deibel, Katelynn E.
Hutcherson, Shelby M.
Jones, Tyler A.
Wang, Zhaoquan
Yang, Chao
Yang, Yong-Kang
Pomerantz, Joel L.
Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease
title Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease
title_full Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease
title_fullStr Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease
title_full_unstemmed Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease
title_short Mechanisms of Regulated and Dysregulated CARD11 Signaling in Adaptive Immunity and Disease
title_sort mechanisms of regulated and dysregulated card11 signaling in adaptive immunity and disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156143/
https://www.ncbi.nlm.nih.gov/pubmed/30283447
http://dx.doi.org/10.3389/fimmu.2018.02105
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