Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis

The common chemical method to synthesize Phenolic Acids (PAs) involves a relatively considerable energy intake. In order to solve this issue, microwave-assisted Knoevenagel-Doebner condensations were developed. Nevertheless, these synthetic procedures prove difficult to reproduce. Herein, we develop...

Descripción completa

Detalles Bibliográficos
Autores principales: Mouterde, Louis M. M., Allais, Florent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156279/
https://www.ncbi.nlm.nih.gov/pubmed/30283775
http://dx.doi.org/10.3389/fchem.2018.00426
_version_ 1783358071945297920
author Mouterde, Louis M. M.
Allais, Florent
author_facet Mouterde, Louis M. M.
Allais, Florent
author_sort Mouterde, Louis M. M.
collection PubMed
description The common chemical method to synthesize Phenolic Acids (PAs) involves a relatively considerable energy intake. In order to solve this issue, microwave-assisted Knoevenagel-Doebner condensations were developed. Nevertheless, these synthetic procedures prove difficult to reproduce. Herein, we developed and optimized—by using a combination of a Design of Experiment and a standard optimization approach—a reliable procedure that converts naturally occuring p-hydroxybenzaldehydes into the corresponding PAs with conversions of 86–99% and in 85–97% yields.
format Online
Article
Text
id pubmed-6156279
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-61562792018-10-03 Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis Mouterde, Louis M. M. Allais, Florent Front Chem Chemistry The common chemical method to synthesize Phenolic Acids (PAs) involves a relatively considerable energy intake. In order to solve this issue, microwave-assisted Knoevenagel-Doebner condensations were developed. Nevertheless, these synthetic procedures prove difficult to reproduce. Herein, we developed and optimized—by using a combination of a Design of Experiment and a standard optimization approach—a reliable procedure that converts naturally occuring p-hydroxybenzaldehydes into the corresponding PAs with conversions of 86–99% and in 85–97% yields. Frontiers Media S.A. 2018-09-19 /pmc/articles/PMC6156279/ /pubmed/30283775 http://dx.doi.org/10.3389/fchem.2018.00426 Text en Copyright © 2018 Mouterde and Allais. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Mouterde, Louis M. M.
Allais, Florent
Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis
title Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis
title_full Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis
title_fullStr Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis
title_full_unstemmed Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis
title_short Microwave-Assisted Knoevenagel-Doebner Reaction: An Efficient Method for Naturally Occurring Phenolic Acids Synthesis
title_sort microwave-assisted knoevenagel-doebner reaction: an efficient method for naturally occurring phenolic acids synthesis
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156279/
https://www.ncbi.nlm.nih.gov/pubmed/30283775
http://dx.doi.org/10.3389/fchem.2018.00426
work_keys_str_mv AT mouterdelouismm microwaveassistedknoevenageldoebnerreactionanefficientmethodfornaturallyoccurringphenolicacidssynthesis
AT allaisflorent microwaveassistedknoevenageldoebnerreactionanefficientmethodfornaturallyoccurringphenolicacidssynthesis

Ejemplares similares