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Cortical modulation of sensory flow during active touch in the rat whisker system

Sensory gating, where responses to stimuli during sensor motion are reduced in amplitude, is a hallmark of active sensing systems. In the rodent whisker system, sensory gating has been described only at the thalamic and cortical stages of sensory processing. However, does sensory gating originate at...

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Autores principales: Chakrabarti, Shubhodeep, Schwarz, Cornelius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156333/
https://www.ncbi.nlm.nih.gov/pubmed/30254195
http://dx.doi.org/10.1038/s41467-018-06200-6
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author Chakrabarti, Shubhodeep
Schwarz, Cornelius
author_facet Chakrabarti, Shubhodeep
Schwarz, Cornelius
author_sort Chakrabarti, Shubhodeep
collection PubMed
description Sensory gating, where responses to stimuli during sensor motion are reduced in amplitude, is a hallmark of active sensing systems. In the rodent whisker system, sensory gating has been described only at the thalamic and cortical stages of sensory processing. However, does sensory gating originate at an even earlier synaptic level? Most importantly, is sensory gating under top-down or bottom-up control? To address these questions, we used an active touch task in behaving rodents while recording from the trigeminal sensory nuclei. First, we show that sensory gating occurs in the brainstem at the first synaptic level. Second, we demonstrate that sensory gating is pathway-specific, present in the lemniscal but not in the extralemniscal stream. Third, using cortical lesions resulting in the complete abolition of sensory gating, we demonstrate its cortical dependence. Fourth, we show accompanying decreases in whisking-related activity, which could be the putative gating signal.
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spelling pubmed-61563332018-09-27 Cortical modulation of sensory flow during active touch in the rat whisker system Chakrabarti, Shubhodeep Schwarz, Cornelius Nat Commun Article Sensory gating, where responses to stimuli during sensor motion are reduced in amplitude, is a hallmark of active sensing systems. In the rodent whisker system, sensory gating has been described only at the thalamic and cortical stages of sensory processing. However, does sensory gating originate at an even earlier synaptic level? Most importantly, is sensory gating under top-down or bottom-up control? To address these questions, we used an active touch task in behaving rodents while recording from the trigeminal sensory nuclei. First, we show that sensory gating occurs in the brainstem at the first synaptic level. Second, we demonstrate that sensory gating is pathway-specific, present in the lemniscal but not in the extralemniscal stream. Third, using cortical lesions resulting in the complete abolition of sensory gating, we demonstrate its cortical dependence. Fourth, we show accompanying decreases in whisking-related activity, which could be the putative gating signal. Nature Publishing Group UK 2018-09-25 /pmc/articles/PMC6156333/ /pubmed/30254195 http://dx.doi.org/10.1038/s41467-018-06200-6 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Chakrabarti, Shubhodeep
Schwarz, Cornelius
Cortical modulation of sensory flow during active touch in the rat whisker system
title Cortical modulation of sensory flow during active touch in the rat whisker system
title_full Cortical modulation of sensory flow during active touch in the rat whisker system
title_fullStr Cortical modulation of sensory flow during active touch in the rat whisker system
title_full_unstemmed Cortical modulation of sensory flow during active touch in the rat whisker system
title_short Cortical modulation of sensory flow during active touch in the rat whisker system
title_sort cortical modulation of sensory flow during active touch in the rat whisker system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156333/
https://www.ncbi.nlm.nih.gov/pubmed/30254195
http://dx.doi.org/10.1038/s41467-018-06200-6
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