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An Internally Controlled Quantitative Target Occupancy Assay for Covalent Inhibitors
Assessing target occupancy is critical for establishing proof-of-mechanism for novel inhibitors and to determine whether robust target inhibition can be achieved at tolerated doses. This is challenging in the clinic using conventional methods due to the need for untreated controls. We describe a new...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156402/ https://www.ncbi.nlm.nih.gov/pubmed/30254226 http://dx.doi.org/10.1038/s41598-018-32683-w |