Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long‐lived animals

Disruption of mitochondrial metabolism and loss of mitochondrial DNA (mtDNA) integrity are widely considered as evolutionarily conserved (public) mechanisms of aging (López‐Otín et al., Cell, 153, 2013 and 1194). Human aging is associated with loss in skeletal muscle mass and function (Sarcopenia),...

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Detalles Bibliográficos
Autores principales: Lakshmanan, Lakshmi Narayanan, Yee, Zhuangli, Ng, Li Fang, Gunawan, Rudiyanto, Halliwell, Barry, Gruber, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156498/
https://www.ncbi.nlm.nih.gov/pubmed/30043489
http://dx.doi.org/10.1111/acel.12814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156498/
https://www.ncbi.nlm.nih.gov/pubmed/30043489
http://dx.doi.org/10.1111/acel.12814

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