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Site-1 protease function is essential for the generation of antibody secreting cells and reprogramming for secretory activity

The unfolded protein response (UPR) and activation of XBP1 is necessary for high secretory efficiency and functional differentiation of antibody secreting cells (ASCs). The UPR additionally includes a branch in which membrane-bound transcription factors, exemplified by ATF6, undergo intramembrane-pr...

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Detalles Bibliográficos
Autores principales:	Al-Maskari, Muna, Care, Matthew A., Robinson, Emily, Cocco, Mario, Tooze, Reuben M., Doody, Gina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156501/ https://www.ncbi.nlm.nih.gov/pubmed/30254311 http://dx.doi.org/10.1038/s41598-018-32705-7

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