Cargando…

Insights into gold nanoparticles as a mucoadhesive system

A large number of drugs are administered on different mucosal surfaces. However, due to the poor mucoadhesion of the current formulations, their bioavailability is often very low. The development of efficient mucoadhesive drug delivery systems is thus crucial for improving the performance of these d...

Descripción completa

Detalles Bibliográficos
Autores principales: Ouellette, Mathieu, Masse, Florence, Lefebvre-Demers, Mathilde, Maestracci, Quentin, Grenier, Philippe, Millar, Robert, Bertrand, Nicolas, Prieto, Manuel, Boisselier, Élodie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156509/
https://www.ncbi.nlm.nih.gov/pubmed/30254340
http://dx.doi.org/10.1038/s41598-018-32699-2
_version_ 1783358119181549568
author Ouellette, Mathieu
Masse, Florence
Lefebvre-Demers, Mathilde
Maestracci, Quentin
Grenier, Philippe
Millar, Robert
Bertrand, Nicolas
Prieto, Manuel
Boisselier, Élodie
author_facet Ouellette, Mathieu
Masse, Florence
Lefebvre-Demers, Mathilde
Maestracci, Quentin
Grenier, Philippe
Millar, Robert
Bertrand, Nicolas
Prieto, Manuel
Boisselier, Élodie
author_sort Ouellette, Mathieu
collection PubMed
description A large number of drugs are administered on different mucosal surfaces. However, due to the poor mucoadhesion of the current formulations, their bioavailability is often very low. The development of efficient mucoadhesive drug delivery systems is thus crucial for improving the performance of these drugs. The mucoadhesive properties of gold nanoparticles were investigated. First, two types of gold nanoparticles were synthesized: AuNP1 and AuNP2. AuNP1 only contain internal thiol groups on their metallic core, and AuNP2 contain both internal and peripheral thiol groups. Different protocols based on an adapted quantitative colorimetric method, UV-visible and fluorescence spectroscopies were then developed to gather information on their mucoadhesive properties. Moreover, a global correction factor for the inner filter effect in spectrofluorimetry was proposed, and the data obtained were compared to those commonly used in the literature. Mucins deeply interact with AuNP1, perturbing their core, whereas they remain at the periphery of AuNP2. The quantitative method suggests that a larger number of mucins interact with AuNP2. The establishment of this protocol could be applied to assess the mucoadhesive properties of other stable molecules. This mucoadhesive property of gold nanoparticles could be combined with their drug delivery ability in order to improve the medication administered on mucosa.
format Online
Article
Text
id pubmed-6156509
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-61565092018-09-28 Insights into gold nanoparticles as a mucoadhesive system Ouellette, Mathieu Masse, Florence Lefebvre-Demers, Mathilde Maestracci, Quentin Grenier, Philippe Millar, Robert Bertrand, Nicolas Prieto, Manuel Boisselier, Élodie Sci Rep Article A large number of drugs are administered on different mucosal surfaces. However, due to the poor mucoadhesion of the current formulations, their bioavailability is often very low. The development of efficient mucoadhesive drug delivery systems is thus crucial for improving the performance of these drugs. The mucoadhesive properties of gold nanoparticles were investigated. First, two types of gold nanoparticles were synthesized: AuNP1 and AuNP2. AuNP1 only contain internal thiol groups on their metallic core, and AuNP2 contain both internal and peripheral thiol groups. Different protocols based on an adapted quantitative colorimetric method, UV-visible and fluorescence spectroscopies were then developed to gather information on their mucoadhesive properties. Moreover, a global correction factor for the inner filter effect in spectrofluorimetry was proposed, and the data obtained were compared to those commonly used in the literature. Mucins deeply interact with AuNP1, perturbing their core, whereas they remain at the periphery of AuNP2. The quantitative method suggests that a larger number of mucins interact with AuNP2. The establishment of this protocol could be applied to assess the mucoadhesive properties of other stable molecules. This mucoadhesive property of gold nanoparticles could be combined with their drug delivery ability in order to improve the medication administered on mucosa. Nature Publishing Group UK 2018-09-25 /pmc/articles/PMC6156509/ /pubmed/30254340 http://dx.doi.org/10.1038/s41598-018-32699-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ouellette, Mathieu
Masse, Florence
Lefebvre-Demers, Mathilde
Maestracci, Quentin
Grenier, Philippe
Millar, Robert
Bertrand, Nicolas
Prieto, Manuel
Boisselier, Élodie
Insights into gold nanoparticles as a mucoadhesive system
title Insights into gold nanoparticles as a mucoadhesive system
title_full Insights into gold nanoparticles as a mucoadhesive system
title_fullStr Insights into gold nanoparticles as a mucoadhesive system
title_full_unstemmed Insights into gold nanoparticles as a mucoadhesive system
title_short Insights into gold nanoparticles as a mucoadhesive system
title_sort insights into gold nanoparticles as a mucoadhesive system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156509/
https://www.ncbi.nlm.nih.gov/pubmed/30254340
http://dx.doi.org/10.1038/s41598-018-32699-2
work_keys_str_mv AT ouellettemathieu insightsintogoldnanoparticlesasamucoadhesivesystem
AT masseflorence insightsintogoldnanoparticlesasamucoadhesivesystem
AT lefebvredemersmathilde insightsintogoldnanoparticlesasamucoadhesivesystem
AT maestracciquentin insightsintogoldnanoparticlesasamucoadhesivesystem
AT grenierphilippe insightsintogoldnanoparticlesasamucoadhesivesystem
AT millarrobert insightsintogoldnanoparticlesasamucoadhesivesystem
AT bertrandnicolas insightsintogoldnanoparticlesasamucoadhesivesystem
AT prietomanuel insightsintogoldnanoparticlesasamucoadhesivesystem
AT boisselierelodie insightsintogoldnanoparticlesasamucoadhesivesystem