Increased transport of acetyl‐CoA into the endoplasmic reticulum causes a progeria‐like phenotype

The membrane transporter AT‐1/SLC33A1 translocates cytosolic acetyl‐CoA into the lumen of the endoplasmic reticulum (ER), participating in quality control mechanisms within the secretory pathway. Mutations and duplication events in AT‐1/SLC33A1 are highly pleiotropic and have been linked to diseases...

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Detalles Bibliográficos
Autores principales: Peng, Yajing, Shapiro, Samantha L., Banduseela, Varuna C., Dieterich, Inca A., Hewitt, Kyle J., Bresnick, Emery H., Kong, Guangyao, Zhang, Jing, Schueler, Kathryn L., Keller, Mark P., Attie, Alan D., Hacker, Timothy A., Sullivan, Ruth, Kielar‐Grevstad, Elle, Arriola Apelo, Sebastian I., Lamming, Dudley W., Anderson, Rozalyn M., Puglielli, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156544/
https://www.ncbi.nlm.nih.gov/pubmed/30051577
http://dx.doi.org/10.1111/acel.12820

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