Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

The lack of effective therapies to limit neurovascular injury in ischemic retinopathy is a major clinical problem. This study aimed to examine the role of ureohydrolase enzyme, arginase 1 (A1), in retinal ischemia-reperfusion (IR) injury. A1 competes with nitric oxide synthase (NOS) for their common...

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Detalles Bibliográficos
Autores principales: Fouda, Abdelrahman Y., Xu, Zhimin, Shosha, Esraa, Lemtalsi, Tahira, Chen, Jijun, Toque, Haroldo A., Tritz, Rebekah, Cui, Xuezhi, Stansfield, Brian K., Huo, Yuqing, Rodriguez, Paulo C., Smith, Sylvia B., Caldwell, R. William, Narayanan, S. Priya, Caldwell, Ruth B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156564/
https://www.ncbi.nlm.nih.gov/pubmed/30254218
http://dx.doi.org/10.1038/s41419-018-1051-6

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