The lantibiotic nukacin ISK-1 exists in an equilibrium between active and inactive lipid-II binding states

The lantibiotic nukacin ISK-1 exerts antimicrobial activity through binding to lipid II. Here, we perform NMR analyses of the structure of nukacin ISK-1 and the interaction with lipid II. Unexpectedly, nukacin ISK-1 exists in two structural states in aqueous solution, with an interconversion rate on...

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Detalles Bibliográficos
Autores principales: Fujinami, Daisuke, -Mahin, Abdullah-Al, Elsayed, Khaled M., Islam, Mohammad R., Nagao, Jun-ichi, Roy, Urmi, Momin, Sabrina, Zendo, Takeshi, Kohda, Daisuke, Sonomoto, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156582/
https://www.ncbi.nlm.nih.gov/pubmed/30272026
http://dx.doi.org/10.1038/s42003-018-0150-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156582/
https://www.ncbi.nlm.nih.gov/pubmed/30272026
http://dx.doi.org/10.1038/s42003-018-0150-3

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