A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability

Cytokinetic abscission facilitates the irreversible separation of daughter cells. This process requires the endosomal-sorting complexes required for transport (ESCRT) machinery and is tightly regulated by charged multivesicular body protein 4C (CHMP4C), an ESCRT-III subunit that engages the abscissi...

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Detalles Bibliográficos
Autores principales: Sadler, Jessica B. A., Wenzel, Dawn M., Strohacker, Lauren K., Guindo-Martínez, Marta, Alam, Steven L., Mercader, Josep M., Torrents, David, Ullman, Katharine S., Sundquist, Wesley I., Martin-Serrano, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156662/
https://www.ncbi.nlm.nih.gov/pubmed/30181294
http://dx.doi.org/10.1073/pnas.1805504115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156662/
https://www.ncbi.nlm.nih.gov/pubmed/30181294
http://dx.doi.org/10.1073/pnas.1805504115

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