Cargando…
Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis
We have performed whole transcriptome sequencing of 5-FU resistant and 5-FU sensitive tumors generated in a mouse model of de novo carcinogenesis that closely recapitulates tumor initiation, progression and maintenance in vivo. Tumors were generated using the DMBA/TPA model of chemically induced car...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156738/ https://www.ncbi.nlm.nih.gov/pubmed/30263912 http://dx.doi.org/10.1016/j.dib.2018.08.209 |
_version_ | 1783358154116956160 |
---|---|
author | Iacovides, Demetris Loizides, Charalambos Mitsis, Georgios Strati, Katerina |
author_facet | Iacovides, Demetris Loizides, Charalambos Mitsis, Georgios Strati, Katerina |
author_sort | Iacovides, Demetris |
collection | PubMed |
description | We have performed whole transcriptome sequencing of 5-FU resistant and 5-FU sensitive tumors generated in a mouse model of de novo carcinogenesis that closely recapitulates tumor initiation, progression and maintenance in vivo. Tumors were generated using the DMBA/TPA model of chemically induced carcinogenesis [1], tumor-bearing mice were subsequently treated with 5-FU, and tumor growth as well as response to treatment was monitored by measuring tumor volume twice a week. Based on these measurements, we selected two 5-FU resistant and two 5-FU sensitive tumors and performed whole transcriptome sequencing and in order to identify differentially expressed transcripts between the two sets. Data obtained is deposited and available through NCBI SRA (reference number SRP155180 – https://www.ncbi.nlm.nih.gov/sra/?term=SRP155180). |
format | Online Article Text |
id | pubmed-6156738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-61567382018-09-27 Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis Iacovides, Demetris Loizides, Charalambos Mitsis, Georgios Strati, Katerina Data Brief Genetics, Genomics and Molecular Biology We have performed whole transcriptome sequencing of 5-FU resistant and 5-FU sensitive tumors generated in a mouse model of de novo carcinogenesis that closely recapitulates tumor initiation, progression and maintenance in vivo. Tumors were generated using the DMBA/TPA model of chemically induced carcinogenesis [1], tumor-bearing mice were subsequently treated with 5-FU, and tumor growth as well as response to treatment was monitored by measuring tumor volume twice a week. Based on these measurements, we selected two 5-FU resistant and two 5-FU sensitive tumors and performed whole transcriptome sequencing and in order to identify differentially expressed transcripts between the two sets. Data obtained is deposited and available through NCBI SRA (reference number SRP155180 – https://www.ncbi.nlm.nih.gov/sra/?term=SRP155180). Elsevier 2018-09-07 /pmc/articles/PMC6156738/ /pubmed/30263912 http://dx.doi.org/10.1016/j.dib.2018.08.209 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Genetics, Genomics and Molecular Biology Iacovides, Demetris Loizides, Charalambos Mitsis, Georgios Strati, Katerina Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis |
title | Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis |
title_full | Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis |
title_fullStr | Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis |
title_full_unstemmed | Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis |
title_short | Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis |
title_sort | whole transcriptome sequence data of 5-fu sensitive and 5-fu resistant tumors generated in a mouse model of de novo carcinogenesis |
topic | Genetics, Genomics and Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156738/ https://www.ncbi.nlm.nih.gov/pubmed/30263912 http://dx.doi.org/10.1016/j.dib.2018.08.209 |
work_keys_str_mv | AT iacovidesdemetris wholetranscriptomesequencedataof5fusensitiveand5furesistanttumorsgeneratedinamousemodelofdenovocarcinogenesis AT loizidescharalambos wholetranscriptomesequencedataof5fusensitiveand5furesistanttumorsgeneratedinamousemodelofdenovocarcinogenesis AT mitsisgeorgios wholetranscriptomesequencedataof5fusensitiveand5furesistanttumorsgeneratedinamousemodelofdenovocarcinogenesis AT stratikaterina wholetranscriptomesequencedataof5fusensitiveand5furesistanttumorsgeneratedinamousemodelofdenovocarcinogenesis |