Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irreversible and severe vision loss in the developed countries. It has been suggested that the pathogenesis of dry AMD involves impaired protein degradation in retinal pigment epithelial cells (RPE). RPE...

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Detalles Bibliográficos
Autores principales: Felszeghy, Szabolcs, Viiri, Johanna, Paterno, Jussi J., Hyttinen, Juha M.T., Koskela, Ali, Chen, Mei, Leinonen, Henri, Tanila, Heikki, Kivinen, Niko, Koistinen, Arto, Toropainen, Elisa, Amadio, Marialaura, Smedowski, Adrian, Reinisalo, Mika, Winiarczyk, Mateusz, Mackiewicz, Jerzy, Mutikainen, Maija, Ruotsalainen, Anna-Kaisa, Kettunen, Mikko, Jokivarsi, Kimmo, Sinha, Debasish, Kinnunen, Kati, Petrovski, Goran, Blasiak, Janusz, Bjørkøy, Geir, Koskelainen, Ari, Skottman, Heli, Urtti, Arto, Salminen, Antero, Kannan, Ram, Ferrington, Deborah A., Xu, Heping, Levonen, Anna-Liisa, Tavi, Pasi, Kauppinen, Anu, Kaarniranta, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156745/
https://www.ncbi.nlm.nih.gov/pubmed/30253279
http://dx.doi.org/10.1016/j.redox.2018.09.011

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