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Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity

AMP-activated protein kinase (AMPK) is a key regulator of cellular and systemic energy homeostasis which achieves this through the phosphorylation of a myriad of downstream targets. One target is TBC1D1 a Rab-GTPase-activating protein that regulates glucose uptake in muscle cells by integrating insu...

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Detalles Bibliográficos
Autores principales:	Thomas, Elaine C., Hook, Sharon C., Gray, Alexander, Chadt, Alexandra, Carling, David, Al-Hasani, Hadi, Heesom, Kate J., Hardie, D. Grahame, Tavaré, Jeremy M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156765/ https://www.ncbi.nlm.nih.gov/pubmed/30135087 http://dx.doi.org/10.1042/BCJ20180475

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