HIRA directly targets the enhancers of selected cardiac transcription factors during in vitro differentiation of mouse embryonic stem cells

HIRA is a histone chaperone known to modulate gene expression through the deposition of H3.3. Conditional knockout of Hira in embryonic mouse hearts leads to cardiac septal defects. Loss of function mutation in HIRA, together with other chromatin modifiers, was found in patients with congenital hear...

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Detalles Bibliográficos
Autores principales: Saleh, Rasha Noureldin M., Dilg, Daniel, Abou Zeid, Abla A., Hashad, Doaa I., Scambler, Peter J., Chapgier, Ariane L. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156767/
https://www.ncbi.nlm.nih.gov/pubmed/30030774
http://dx.doi.org/10.1007/s11033-018-4247-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156767/
https://www.ncbi.nlm.nih.gov/pubmed/30030774
http://dx.doi.org/10.1007/s11033-018-4247-z

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