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Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory
PURPOSE: Physiologically-based pharmacokinetic (PBPK) models are essential in drug development, but require parameters that are not always obtainable. We developed a methodology to investigate the feasibility and requirements for precise and accurate estimation of PBPK parameters using population mo...
Autores principales: | Calvier, Elisa A. M., Nguyen, Thu Thuy, Johnson, Trevor N., Rostami-Hodjegan, Amin, Tibboel, Dick, Krekels, Elke H. J., Knibbe, Catherijne A. J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156772/ https://www.ncbi.nlm.nih.gov/pubmed/30218393 http://dx.doi.org/10.1007/s11095-018-2487-1 |
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