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Precision medicine in COPD: where are we and where do we need to go?

Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical pr...

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Detalles Bibliográficos
Autores principales: Sidhaye, Venkataramana K., Nishida, Kristine, Martinez, Fernando J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156790/
https://www.ncbi.nlm.nih.gov/pubmed/30068688
http://dx.doi.org/10.1183/16000617.0022-2018
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author Sidhaye, Venkataramana K.
Nishida, Kristine
Martinez, Fernando J.
author_facet Sidhaye, Venkataramana K.
Nishida, Kristine
Martinez, Fernando J.
author_sort Sidhaye, Venkataramana K.
collection PubMed
description Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Given the complexity of the disease we propose a precision medicine approach to understanding and better treating COPD. It is possible that multiOMICs can be used as a tool to integrate data from multiple fields. Moreover, analysis of electronic medical records could aid in the treatment of patients and in the predictions of outcomes. The Precision Medicine Initiative created in 2015 has made precision medicine approaches to treat disease a reality; one of these diseases being COPD.
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spelling pubmed-61567902018-09-30 Precision medicine in COPD: where are we and where do we need to go? Sidhaye, Venkataramana K. Nishida, Kristine Martinez, Fernando J. Eur Respir Rev Series Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Given the complexity of the disease we propose a precision medicine approach to understanding and better treating COPD. It is possible that multiOMICs can be used as a tool to integrate data from multiple fields. Moreover, analysis of electronic medical records could aid in the treatment of patients and in the predictions of outcomes. The Precision Medicine Initiative created in 2015 has made precision medicine approaches to treat disease a reality; one of these diseases being COPD. European Respiratory Society 2018-08-01 /pmc/articles/PMC6156790/ /pubmed/30068688 http://dx.doi.org/10.1183/16000617.0022-2018 Text en Copyright ©ERS 2018. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Series
Sidhaye, Venkataramana K.
Nishida, Kristine
Martinez, Fernando J.
Precision medicine in COPD: where are we and where do we need to go?
title Precision medicine in COPD: where are we and where do we need to go?
title_full Precision medicine in COPD: where are we and where do we need to go?
title_fullStr Precision medicine in COPD: where are we and where do we need to go?
title_full_unstemmed Precision medicine in COPD: where are we and where do we need to go?
title_short Precision medicine in COPD: where are we and where do we need to go?
title_sort precision medicine in copd: where are we and where do we need to go?
topic Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156790/
https://www.ncbi.nlm.nih.gov/pubmed/30068688
http://dx.doi.org/10.1183/16000617.0022-2018
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