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Precision medicine in COPD: where are we and where do we need to go?
Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical pr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156790/ https://www.ncbi.nlm.nih.gov/pubmed/30068688 http://dx.doi.org/10.1183/16000617.0022-2018 |
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author | Sidhaye, Venkataramana K. Nishida, Kristine Martinez, Fernando J. |
author_facet | Sidhaye, Venkataramana K. Nishida, Kristine Martinez, Fernando J. |
author_sort | Sidhaye, Venkataramana K. |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Given the complexity of the disease we propose a precision medicine approach to understanding and better treating COPD. It is possible that multiOMICs can be used as a tool to integrate data from multiple fields. Moreover, analysis of electronic medical records could aid in the treatment of patients and in the predictions of outcomes. The Precision Medicine Initiative created in 2015 has made precision medicine approaches to treat disease a reality; one of these diseases being COPD. |
format | Online Article Text |
id | pubmed-6156790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-61567902018-09-30 Precision medicine in COPD: where are we and where do we need to go? Sidhaye, Venkataramana K. Nishida, Kristine Martinez, Fernando J. Eur Respir Rev Series Chronic obstructive pulmonary disease (COPD) was the fourth leading cause of death worldwide in 2015. Current treatments for patients ease discomfort and help decrease disease progression; however, none improve lung function or change mortality. COPD is heterogeneous in its molecular and clinical presentation, making it difficult to understand disease aetiology and define robust therapeutic strategies. Given the complexity of the disease we propose a precision medicine approach to understanding and better treating COPD. It is possible that multiOMICs can be used as a tool to integrate data from multiple fields. Moreover, analysis of electronic medical records could aid in the treatment of patients and in the predictions of outcomes. The Precision Medicine Initiative created in 2015 has made precision medicine approaches to treat disease a reality; one of these diseases being COPD. European Respiratory Society 2018-08-01 /pmc/articles/PMC6156790/ /pubmed/30068688 http://dx.doi.org/10.1183/16000617.0022-2018 Text en Copyright ©ERS 2018. https://creativecommons.org/licenses/by-nc/4.0/ERR articles are open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Series Sidhaye, Venkataramana K. Nishida, Kristine Martinez, Fernando J. Precision medicine in COPD: where are we and where do we need to go? |
title | Precision medicine in COPD: where are we and where do we need to go? |
title_full | Precision medicine in COPD: where are we and where do we need to go? |
title_fullStr | Precision medicine in COPD: where are we and where do we need to go? |
title_full_unstemmed | Precision medicine in COPD: where are we and where do we need to go? |
title_short | Precision medicine in COPD: where are we and where do we need to go? |
title_sort | precision medicine in copd: where are we and where do we need to go? |
topic | Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156790/ https://www.ncbi.nlm.nih.gov/pubmed/30068688 http://dx.doi.org/10.1183/16000617.0022-2018 |
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