Cargando…
A drug screening assay on cancer cells chronically adapted to acidosis
BACKGROUND: Drug screening for the identification of compounds with anticancer activity is commonly performed using cell lines cultured under normal oxygen pressure and physiological pH. However, solid tumors are characterized by a microenvironment with limited access to nutrients, reduced oxygen su...
Autores principales: | Pellegrini, Paola, Serviss, Jason T., Lundbäck, Thomas, Bancaro, Nicolo, Mazurkiewicz, Magdalena, Kolosenko, Iryna, Yu, Di, Haraldsson, Martin, D’Arcy, Padraig, Linder, Stig, De Milito, Angelo |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156858/ https://www.ncbi.nlm.nih.gov/pubmed/30263014 http://dx.doi.org/10.1186/s12935-018-0645-5 |
Ejemplares similares
-
STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes
por: Edsbäcker, Elin, et al.
Publicado: (2019) -
Proteasome-associated deubiquitinases and cancer
por: Mofers, Arjan, et al.
Publicado: (2017) -
Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
por: Mazurkiewicz, Magdalena, et al.
Publicado: (2017) -
Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors
por: Zhang, Xiaonan, et al.
Publicado: (2015) -
Analysis of determinants for in vitro resistance to the small molecule deubiquitinase inhibitor b-AP15
por: Mofers, Arjan, et al.
Publicado: (2019)