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Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016

BACKGROUND: According to the World Health Organization, Nigeria is one of the countries with a high burden of tuberculosis (TB) worldwide. Improving the burden of TB among HIV-negative people would require comprehensive and up-to-date data to inform targeted policy actions in Nigeria. The study aime...

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Autores principales: Ogbo, Felix Akpojene, Ogeleka, Pascal, Okoro, Anselm, Olusanya, Bolajoko O., Olusanya, Jacob, Ifegwu, Ifegwu K., Awosemo, Akorede O., Eastwood, John, Page, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156953/
https://www.ncbi.nlm.nih.gov/pubmed/30262990
http://dx.doi.org/10.1186/s41182-018-0114-9
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author Ogbo, Felix Akpojene
Ogeleka, Pascal
Okoro, Anselm
Olusanya, Bolajoko O.
Olusanya, Jacob
Ifegwu, Ifegwu K.
Awosemo, Akorede O.
Eastwood, John
Page, Andrew
author_facet Ogbo, Felix Akpojene
Ogeleka, Pascal
Okoro, Anselm
Olusanya, Bolajoko O.
Olusanya, Jacob
Ifegwu, Ifegwu K.
Awosemo, Akorede O.
Eastwood, John
Page, Andrew
author_sort Ogbo, Felix Akpojene
collection PubMed
description BACKGROUND: According to the World Health Organization, Nigeria is one of the countries with a high burden of tuberculosis (TB) worldwide. Improving the burden of TB among HIV-negative people would require comprehensive and up-to-date data to inform targeted policy actions in Nigeria. The study aimed to describe the incidence, prevalence, mortality, disability-adjusted life years (DALYs) and risk factors of tuberculosis in Nigeria between 1990 and 2016. METHODS: This study used the most recent data from the global burden of disease study 2016. TB deaths were estimated using the Cause of Death Ensemble model, while TB incidence, prevalence and DALYs, as well as years of life lost and years of life lived with disability were calculated in the DisMod-MR 2.1, a Bayesian meta-regression tool. Using a comparative risk assessment approach, TB burden attributable to risk factors was estimated in a spatial-temporal Gaussian Process Regression tool. RESULTS: In 2016, the prevalence of TB among HIV-negative people was 27% (95% uncertainty interval [95% UI] 23–31%) in Nigeria. TB incidence rate (new and relapse cases) was 158 per 100,000 people (95% UI; 128-193), while the total number of TB mortality was 39,933 deaths (95% UI; 30,488-55,039) in 2016. Between 2000 and 2016, the age-standardised prevalence and incidence rates of TB-HIV negative decreased by 20.0 and 87.6%, respectively. The age-standardised mortality rate also dropped by 191.6% over the same period. DALYs due to TB among HIV-negative Nigerians was high but varied across the age groups. Of the risk factors studied, alcohol use accounted for the highest number of TB deaths and DALYs, followed by diabetes and smoking in 2016. CONCLUSION: The study shows an improving trend in TB disease burden among HIV-negative individuals in Nigeria from 1990 to 2016. Despite this progress, this study suggests that additional efforts are still needed to ensure that Nigeria is not left behind in the current global strategy to end TB disease. Reducing TB disease burden in the country will require a multipronged approach that includes increased funding, health system strengthening and improved TB surveillance, as well as preventive efforts for alcohol use, smoking and diabetes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s41182-018-0114-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-61569532018-09-27 Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016 Ogbo, Felix Akpojene Ogeleka, Pascal Okoro, Anselm Olusanya, Bolajoko O. Olusanya, Jacob Ifegwu, Ifegwu K. Awosemo, Akorede O. Eastwood, John Page, Andrew Trop Med Health Research BACKGROUND: According to the World Health Organization, Nigeria is one of the countries with a high burden of tuberculosis (TB) worldwide. Improving the burden of TB among HIV-negative people would require comprehensive and up-to-date data to inform targeted policy actions in Nigeria. The study aimed to describe the incidence, prevalence, mortality, disability-adjusted life years (DALYs) and risk factors of tuberculosis in Nigeria between 1990 and 2016. METHODS: This study used the most recent data from the global burden of disease study 2016. TB deaths were estimated using the Cause of Death Ensemble model, while TB incidence, prevalence and DALYs, as well as years of life lost and years of life lived with disability were calculated in the DisMod-MR 2.1, a Bayesian meta-regression tool. Using a comparative risk assessment approach, TB burden attributable to risk factors was estimated in a spatial-temporal Gaussian Process Regression tool. RESULTS: In 2016, the prevalence of TB among HIV-negative people was 27% (95% uncertainty interval [95% UI] 23–31%) in Nigeria. TB incidence rate (new and relapse cases) was 158 per 100,000 people (95% UI; 128-193), while the total number of TB mortality was 39,933 deaths (95% UI; 30,488-55,039) in 2016. Between 2000 and 2016, the age-standardised prevalence and incidence rates of TB-HIV negative decreased by 20.0 and 87.6%, respectively. The age-standardised mortality rate also dropped by 191.6% over the same period. DALYs due to TB among HIV-negative Nigerians was high but varied across the age groups. Of the risk factors studied, alcohol use accounted for the highest number of TB deaths and DALYs, followed by diabetes and smoking in 2016. CONCLUSION: The study shows an improving trend in TB disease burden among HIV-negative individuals in Nigeria from 1990 to 2016. Despite this progress, this study suggests that additional efforts are still needed to ensure that Nigeria is not left behind in the current global strategy to end TB disease. Reducing TB disease burden in the country will require a multipronged approach that includes increased funding, health system strengthening and improved TB surveillance, as well as preventive efforts for alcohol use, smoking and diabetes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s41182-018-0114-9) contains supplementary material, which is available to authorized users. BioMed Central 2018-09-25 /pmc/articles/PMC6156953/ /pubmed/30262990 http://dx.doi.org/10.1186/s41182-018-0114-9 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Ogbo, Felix Akpojene
Ogeleka, Pascal
Okoro, Anselm
Olusanya, Bolajoko O.
Olusanya, Jacob
Ifegwu, Ifegwu K.
Awosemo, Akorede O.
Eastwood, John
Page, Andrew
Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016
title Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016
title_full Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016
title_fullStr Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016
title_full_unstemmed Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016
title_short Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016
title_sort tuberculosis disease burden and attributable risk factors in nigeria, 1990–2016
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156953/
https://www.ncbi.nlm.nih.gov/pubmed/30262990
http://dx.doi.org/10.1186/s41182-018-0114-9
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