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Human polyomaviruses and cancer: an overview
The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the capacity of mediating cell transformation and...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157077/ https://www.ncbi.nlm.nih.gov/pubmed/30328951 http://dx.doi.org/10.6061/clinics/2018/e558s |
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author | Prado, José Carlos Mann Monezi, Telma Alves Amorim, Aline Teixeira Lino, Vanesca Paladino, Andressa Boccardo, Enrique |
author_facet | Prado, José Carlos Mann Monezi, Telma Alves Amorim, Aline Teixeira Lino, Vanesca Paladino, Andressa Boccardo, Enrique |
author_sort | Prado, José Carlos Mann |
collection | PubMed |
description | The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the capacity of mediating cell transformation and tumorigenesis in different experimental models. The transformation process mediated by these viruses is driven by viral pleiotropic regulatory proteins called T (tumor) antigens. Similar to other viral oncoproteins T antigens target cellular regulatory factors to favor cell proliferation, immune evasion and downregulation of apoptosis. The first two human polyomaviruses were isolated over 45 years ago. However, recent advances in the DNA sequencing technologies led to the rapid identification of additional twelve new polyomaviruses in different human samples. Many of these viruses establish chronic infections and have been associated with conditions in immunosuppressed individuals, particularly in organ transplant recipients. This has been associated to viral reactivation due to the immunosuppressant therapy applied to these patients. Four polyomaviruses namely, Merkel cell polyomavirus (MCPyV), Trichodysplasia spinulosa polyomavirus (TSPyV), John Cunningham Polyomavirus (JCPyV) and BK polyomavirus (BKPyV) have been associated with the development of specific malignant tumors. However, present evidence only supports the role of MCPyV as a carcinogen to humans. In the present review we present a summarized discussion on the current knowledge concerning the role of MCPyV, TSPyV, JCPyV and BKPyV in human cancers. |
format | Online Article Text |
id | pubmed-6157077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-61570772018-09-27 Human polyomaviruses and cancer: an overview Prado, José Carlos Mann Monezi, Telma Alves Amorim, Aline Teixeira Lino, Vanesca Paladino, Andressa Boccardo, Enrique Clinics (Sao Paulo) Review Article The name of the family Polyomaviridae, derives from the early observation that cells infected with murine polyomavirus induced multiple (poly) tumors (omas) in immunocompromised mice. Subsequent studies showed that many members of this family exhibit the capacity of mediating cell transformation and tumorigenesis in different experimental models. The transformation process mediated by these viruses is driven by viral pleiotropic regulatory proteins called T (tumor) antigens. Similar to other viral oncoproteins T antigens target cellular regulatory factors to favor cell proliferation, immune evasion and downregulation of apoptosis. The first two human polyomaviruses were isolated over 45 years ago. However, recent advances in the DNA sequencing technologies led to the rapid identification of additional twelve new polyomaviruses in different human samples. Many of these viruses establish chronic infections and have been associated with conditions in immunosuppressed individuals, particularly in organ transplant recipients. This has been associated to viral reactivation due to the immunosuppressant therapy applied to these patients. Four polyomaviruses namely, Merkel cell polyomavirus (MCPyV), Trichodysplasia spinulosa polyomavirus (TSPyV), John Cunningham Polyomavirus (JCPyV) and BK polyomavirus (BKPyV) have been associated with the development of specific malignant tumors. However, present evidence only supports the role of MCPyV as a carcinogen to humans. In the present review we present a summarized discussion on the current knowledge concerning the role of MCPyV, TSPyV, JCPyV and BKPyV in human cancers. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2018-09-26 2018 /pmc/articles/PMC6157077/ /pubmed/30328951 http://dx.doi.org/10.6061/clinics/2018/e558s Text en Copyright © 2018 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited. |
spellingShingle | Review Article Prado, José Carlos Mann Monezi, Telma Alves Amorim, Aline Teixeira Lino, Vanesca Paladino, Andressa Boccardo, Enrique Human polyomaviruses and cancer: an overview |
title | Human polyomaviruses and cancer: an overview |
title_full | Human polyomaviruses and cancer: an overview |
title_fullStr | Human polyomaviruses and cancer: an overview |
title_full_unstemmed | Human polyomaviruses and cancer: an overview |
title_short | Human polyomaviruses and cancer: an overview |
title_sort | human polyomaviruses and cancer: an overview |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157077/ https://www.ncbi.nlm.nih.gov/pubmed/30328951 http://dx.doi.org/10.6061/clinics/2018/e558s |
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