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Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges

Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been deve...

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Detalles Bibliográficos
Autores principales: Perše, Martina, Večerić-Haler, Željka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157122/
https://www.ncbi.nlm.nih.gov/pubmed/30276200
http://dx.doi.org/10.1155/2018/1462802
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author Perše, Martina
Večerić-Haler, Željka
author_facet Perše, Martina
Večerić-Haler, Željka
author_sort Perše, Martina
collection PubMed
description Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney injury, which involves both local events in the kidney and interconnected and interdependent systemic effects in the body, cisplatin rodent model is indispensable in the investigation of underlying mechanisms and potential treatment strategies of both acute and chronic kidney injury. Cisplatin rodent model is well appreciated and widely used model due to its simplicity. It has many similarities to human cisplatin nephrotoxicity, which are mentioned in the paper. In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using cisplatin model. The present paper is aimed at giving a concise insight into the complex characteristics of cisplatin rodent model and heterogeneity of cisplatin dosage regimens as well as outlining factors that can severely influence the outcome of the model and the study. Challenges for future research are also mentioned.
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spelling pubmed-61571222018-10-01 Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges Perše, Martina Večerić-Haler, Željka Biomed Res Int Review Article Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the complex pathogenesis of kidney injury, which involves both local events in the kidney and interconnected and interdependent systemic effects in the body, cisplatin rodent model is indispensable in the investigation of underlying mechanisms and potential treatment strategies of both acute and chronic kidney injury. Cisplatin rodent model is well appreciated and widely used model due to its simplicity. It has many similarities to human cisplatin nephrotoxicity, which are mentioned in the paper. In spite of its simplicity and wide applicability, there are also traps that need to be taken into account when using cisplatin model. The present paper is aimed at giving a concise insight into the complex characteristics of cisplatin rodent model and heterogeneity of cisplatin dosage regimens as well as outlining factors that can severely influence the outcome of the model and the study. Challenges for future research are also mentioned. Hindawi 2018-09-12 /pmc/articles/PMC6157122/ /pubmed/30276200 http://dx.doi.org/10.1155/2018/1462802 Text en Copyright © 2018 Martina Perše and Željka Večerić-Haler. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Perše, Martina
Večerić-Haler, Željka
Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges
title Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges
title_full Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges
title_fullStr Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges
title_full_unstemmed Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges
title_short Cisplatin-Induced Rodent Model of Kidney Injury: Characteristics and Challenges
title_sort cisplatin-induced rodent model of kidney injury: characteristics and challenges
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157122/
https://www.ncbi.nlm.nih.gov/pubmed/30276200
http://dx.doi.org/10.1155/2018/1462802
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