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Integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families

Epigenome-wide association studies (EWAS) have traditionally focused on the association test of single epigenetic markers with complex traits. However, it is possible that multiple cytosine-phosphate-guanine (CpG) sites at the same locus could jointly exert their effects on human traits. Therefore,...

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Detalles Bibliográficos
Autores principales: Wang, Biqi, DeStefano, Anita L., Lin, Honghuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157127/
https://www.ncbi.nlm.nih.gov/pubmed/30275882
http://dx.doi.org/10.1186/s12919-018-0125-x
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author Wang, Biqi
DeStefano, Anita L.
Lin, Honghuang
author_facet Wang, Biqi
DeStefano, Anita L.
Lin, Honghuang
author_sort Wang, Biqi
collection PubMed
description Epigenome-wide association studies (EWAS) have traditionally focused on the association test of single epigenetic markers with complex traits. However, it is possible that multiple cytosine-phosphate-guanine (CpG) sites at the same locus could jointly exert their effects on human traits. Therefore, a region-based test that combines multiple markers could be more powerful. We used 2 different region-based tests to investigate the association between changes in DNA methylation and drug response, including the median methylation level test (MMLT) and sequence kernel association test (SKAT). No genes were found to be significantly associated with the drug response (for triglycerides, the false discovery rate ranged from 0.855 to 0.999; for high-density lipoprotein cholesterol, and the false discovery rate ranged from 0.584 to 0.915). Further evidence is needed to explore potential application of gene-level methylation association analysis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12919-018-0125-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-61571272018-10-01 Integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families Wang, Biqi DeStefano, Anita L. Lin, Honghuang BMC Proc Proceedings Epigenome-wide association studies (EWAS) have traditionally focused on the association test of single epigenetic markers with complex traits. However, it is possible that multiple cytosine-phosphate-guanine (CpG) sites at the same locus could jointly exert their effects on human traits. Therefore, a region-based test that combines multiple markers could be more powerful. We used 2 different region-based tests to investigate the association between changes in DNA methylation and drug response, including the median methylation level test (MMLT) and sequence kernel association test (SKAT). No genes were found to be significantly associated with the drug response (for triglycerides, the false discovery rate ranged from 0.855 to 0.999; for high-density lipoprotein cholesterol, and the false discovery rate ranged from 0.584 to 0.915). Further evidence is needed to explore potential application of gene-level methylation association analysis. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12919-018-0125-x) contains supplementary material, which is available to authorized users. BioMed Central 2018-09-17 /pmc/articles/PMC6157127/ /pubmed/30275882 http://dx.doi.org/10.1186/s12919-018-0125-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Proceedings
Wang, Biqi
DeStefano, Anita L.
Lin, Honghuang
Integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families
title Integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families
title_full Integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families
title_fullStr Integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families
title_full_unstemmed Integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families
title_short Integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families
title_sort integrative methylation score to identify epigenetic modifications associated with lipid changes resulting from fenofibrate treatment in families
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157127/
https://www.ncbi.nlm.nih.gov/pubmed/30275882
http://dx.doi.org/10.1186/s12919-018-0125-x
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