Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood

Complex genetic traits are often characterized by multiple quantitative phenotypes. Because values of such phenotypes vary over time, it is thought that analyses of longitudinal data on the phenotypes may lead to increased power in detecting genetic association. In this paper, we extend a transmissi...

Descripción completa

Detalles Bibliográficos
Autores principales: Kulkarni, Hemant, Mukhopadhyay, Indranil, Ghosh, Saurabh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Proceedings
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157161/
https://www.ncbi.nlm.nih.gov/pubmed/30275889
http://dx.doi.org/10.1186/s12919-018-0147-4
_version_ 1783358223510667264
author Kulkarni, Hemant
Mukhopadhyay, Indranil
Ghosh, Saurabh
author_facet Kulkarni, Hemant
Mukhopadhyay, Indranil
Ghosh, Saurabh
author_sort Kulkarni, Hemant
collection PubMed
description Complex genetic traits are often characterized by multiple quantitative phenotypes. Because values of such phenotypes vary over time, it is thought that analyses of longitudinal data on the phenotypes may lead to increased power in detecting genetic association. In this paper, we extend a transmission-based association test applying quasi-likelihood that has been developed by us to the longitudinal framework and to carry out a genome-wide association analysis of triglyceride levels based on the data provided in GAW20. We consider different phenotype definitions based on administration of fenofibrate and obtain significant association findings within genes involved in heart diseases.
format Online
Article
Text
id pubmed-6157161
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-61571612018-10-01 Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood Kulkarni, Hemant Mukhopadhyay, Indranil Ghosh, Saurabh BMC Proc Proceedings Complex genetic traits are often characterized by multiple quantitative phenotypes. Because values of such phenotypes vary over time, it is thought that analyses of longitudinal data on the phenotypes may lead to increased power in detecting genetic association. In this paper, we extend a transmission-based association test applying quasi-likelihood that has been developed by us to the longitudinal framework and to carry out a genome-wide association analysis of triglyceride levels based on the data provided in GAW20. We consider different phenotype definitions based on administration of fenofibrate and obtain significant association findings within genes involved in heart diseases. BioMed Central 2018-09-17 /pmc/articles/PMC6157161/ /pubmed/30275889 http://dx.doi.org/10.1186/s12919-018-0147-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Proceedings
Kulkarni, Hemant
Mukhopadhyay, Indranil
Ghosh, Saurabh
Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood
title Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood
title_full Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood
title_fullStr Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood
title_full_unstemmed Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood
title_short Transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood
title_sort transmission-based association mapping of triglyceride levels in a longitudinal framework using quasi-likelihood
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157161/
https://www.ncbi.nlm.nih.gov/pubmed/30275889
http://dx.doi.org/10.1186/s12919-018-0147-4
work_keys_str_mv AT kulkarnihemant transmissionbasedassociationmappingoftriglyceridelevelsinalongitudinalframeworkusingquasilikelihood
AT mukhopadhyayindranil transmissionbasedassociationmappingoftriglyceridelevelsinalongitudinalframeworkusingquasilikelihood
AT ghoshsaurabh transmissionbasedassociationmappingoftriglyceridelevelsinalongitudinalframeworkusingquasilikelihood

Ejemplares similares