Cargando…
Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital
Brown tumor is a bone lesion that arises in the setting of excess osteoclast activity in hyperparathyroidism. It consists of fibrous tissue, woven bone, and supporting vasculature, while contains no matrix. The characteristic of brown-colored lesion is a result of hemosiderin deposition into the ost...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157168/ https://www.ncbi.nlm.nih.gov/pubmed/30298112 http://dx.doi.org/10.1155/2018/1801652 |
_version_ | 1783358224911564800 |
---|---|
author | Kartini, Diani Siswiandari, Maria K. Wibisana, Gunawan Yulian, Erwin D. Kurnia, Ahmad Panigoro, Sonar S. Albar, Azdi Z. Ramli, Muchlis |
author_facet | Kartini, Diani Siswiandari, Maria K. Wibisana, Gunawan Yulian, Erwin D. Kurnia, Ahmad Panigoro, Sonar S. Albar, Azdi Z. Ramli, Muchlis |
author_sort | Kartini, Diani |
collection | PubMed |
description | Brown tumor is a bone lesion that arises in the setting of excess osteoclast activity in hyperparathyroidism. It consists of fibrous tissue, woven bone, and supporting vasculature, while contains no matrix. The characteristic of brown-colored lesion is a result of hemosiderin deposition into the osteolytic cysts. Two cases of young women aged 26 and 29 years old, respectively, are known with a history of end-stage renal disease (ESRD). Dialysis is performed two times/week over the last 7 years. Our patients presented with an intraoral mass of the hard palate since 12 months ago and decreased body height of 10 cm. The lesion causes difficulties in swallowing and talking. Laboratory workup showed elevated parathormone or PTH (3.391 pg/mL and >5.000 pg/mL). Neck ultrasound showed enlargement of the parathyroid glands. Supporting examination to diagnose brown tumor are neck ultrasound, CT of the neck, and parathyroid sestamibi scan. We performed parathyroidectomy. Pathology revealed hyperplasia of the parathyroid. The tumor regressed significantly within 2 weeks following the surgery, and we still observe tumor regression as well as reduction in PTH level. As clinicians, we should be alert to other possible causes of bony lesions. Clinical examination, laboratory finding, and imaging present important information to diagnose brown tumor. |
format | Online Article Text |
id | pubmed-6157168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-61571682018-10-08 Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital Kartini, Diani Siswiandari, Maria K. Wibisana, Gunawan Yulian, Erwin D. Kurnia, Ahmad Panigoro, Sonar S. Albar, Azdi Z. Ramli, Muchlis Case Rep Oncol Med Case Report Brown tumor is a bone lesion that arises in the setting of excess osteoclast activity in hyperparathyroidism. It consists of fibrous tissue, woven bone, and supporting vasculature, while contains no matrix. The characteristic of brown-colored lesion is a result of hemosiderin deposition into the osteolytic cysts. Two cases of young women aged 26 and 29 years old, respectively, are known with a history of end-stage renal disease (ESRD). Dialysis is performed two times/week over the last 7 years. Our patients presented with an intraoral mass of the hard palate since 12 months ago and decreased body height of 10 cm. The lesion causes difficulties in swallowing and talking. Laboratory workup showed elevated parathormone or PTH (3.391 pg/mL and >5.000 pg/mL). Neck ultrasound showed enlargement of the parathyroid glands. Supporting examination to diagnose brown tumor are neck ultrasound, CT of the neck, and parathyroid sestamibi scan. We performed parathyroidectomy. Pathology revealed hyperplasia of the parathyroid. The tumor regressed significantly within 2 weeks following the surgery, and we still observe tumor regression as well as reduction in PTH level. As clinicians, we should be alert to other possible causes of bony lesions. Clinical examination, laboratory finding, and imaging present important information to diagnose brown tumor. Hindawi 2018-09-12 /pmc/articles/PMC6157168/ /pubmed/30298112 http://dx.doi.org/10.1155/2018/1801652 Text en Copyright © 2018 Diani Kartini et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kartini, Diani Siswiandari, Maria K. Wibisana, Gunawan Yulian, Erwin D. Kurnia, Ahmad Panigoro, Sonar S. Albar, Azdi Z. Ramli, Muchlis Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital |
title | Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital |
title_full | Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital |
title_fullStr | Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital |
title_full_unstemmed | Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital |
title_short | Craniofacial Brown Tumor in Patients with Secondary Hyperparathyroidism to Chronic Renal Failure: Report of Two Cases in Cipto Mangunkusumo Hospital |
title_sort | craniofacial brown tumor in patients with secondary hyperparathyroidism to chronic renal failure: report of two cases in cipto mangunkusumo hospital |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157168/ https://www.ncbi.nlm.nih.gov/pubmed/30298112 http://dx.doi.org/10.1155/2018/1801652 |
work_keys_str_mv | AT kartinidiani craniofacialbrowntumorinpatientswithsecondaryhyperparathyroidismtochronicrenalfailurereportoftwocasesinciptomangunkusumohospital AT siswiandarimariak craniofacialbrowntumorinpatientswithsecondaryhyperparathyroidismtochronicrenalfailurereportoftwocasesinciptomangunkusumohospital AT wibisanagunawan craniofacialbrowntumorinpatientswithsecondaryhyperparathyroidismtochronicrenalfailurereportoftwocasesinciptomangunkusumohospital AT yulianerwind craniofacialbrowntumorinpatientswithsecondaryhyperparathyroidismtochronicrenalfailurereportoftwocasesinciptomangunkusumohospital AT kurniaahmad craniofacialbrowntumorinpatientswithsecondaryhyperparathyroidismtochronicrenalfailurereportoftwocasesinciptomangunkusumohospital AT panigorosonars craniofacialbrowntumorinpatientswithsecondaryhyperparathyroidismtochronicrenalfailurereportoftwocasesinciptomangunkusumohospital AT albarazdiz craniofacialbrowntumorinpatientswithsecondaryhyperparathyroidismtochronicrenalfailurereportoftwocasesinciptomangunkusumohospital AT ramlimuchlis craniofacialbrowntumorinpatientswithsecondaryhyperparathyroidismtochronicrenalfailurereportoftwocasesinciptomangunkusumohospital |