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Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis

Tardive dyskinesia (TD) is a movement disorder that may occur after extended use of antipsychotic medications. The etiopathophysiology is unclear; however, genetic factors play an important role. The Perlecan (HSPG2) gene was found to be significantly associated with TD in Japanese schizophrenia pat...

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Autores principales: Zai, Clement C., Lee, Frankie H., Tiwari, Arun K., Lu, Justin Y., de Luca, Vincenzo, Maes, Miriam S., Herbert, Deanna, Shahmirian, Anashe, Cheema, Sheraz Y., Zai, Gwyneth C., Atukuri, Anupama, Sherman, Michael, Shaikh, Sajid A., Tampakeras, Maria, Freeman, Natalie, King, Nicole, Müller, Daniel J., Greenbaum, Lior, Lerer, Bernard, Voineskos, Aristotle N., Potkin, Steven G., Lieberman, Jeffrey A., Meltzer, Herbert Y., Remington, Gary, Kennedy, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157325/
https://www.ncbi.nlm.nih.gov/pubmed/30283332
http://dx.doi.org/10.3389/fphar.2018.00974
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author Zai, Clement C.
Lee, Frankie H.
Tiwari, Arun K.
Lu, Justin Y.
de Luca, Vincenzo
Maes, Miriam S.
Herbert, Deanna
Shahmirian, Anashe
Cheema, Sheraz Y.
Zai, Gwyneth C.
Atukuri, Anupama
Sherman, Michael
Shaikh, Sajid A.
Tampakeras, Maria
Freeman, Natalie
King, Nicole
Müller, Daniel J.
Greenbaum, Lior
Lerer, Bernard
Voineskos, Aristotle N.
Potkin, Steven G.
Lieberman, Jeffrey A.
Meltzer, Herbert Y.
Remington, Gary
Kennedy, James L.
author_facet Zai, Clement C.
Lee, Frankie H.
Tiwari, Arun K.
Lu, Justin Y.
de Luca, Vincenzo
Maes, Miriam S.
Herbert, Deanna
Shahmirian, Anashe
Cheema, Sheraz Y.
Zai, Gwyneth C.
Atukuri, Anupama
Sherman, Michael
Shaikh, Sajid A.
Tampakeras, Maria
Freeman, Natalie
King, Nicole
Müller, Daniel J.
Greenbaum, Lior
Lerer, Bernard
Voineskos, Aristotle N.
Potkin, Steven G.
Lieberman, Jeffrey A.
Meltzer, Herbert Y.
Remington, Gary
Kennedy, James L.
author_sort Zai, Clement C.
collection PubMed
description Tardive dyskinesia (TD) is a movement disorder that may occur after extended use of antipsychotic medications. The etiopathophysiology is unclear; however, genetic factors play an important role. The Perlecan (HSPG2) gene was found to be significantly associated with TD in Japanese schizophrenia patients, and this association was subsequently replicated by an independent research group. To add to the evidence for this gene in TD, we conducted a meta-analysis specific to the relationship of HSPG2 rs2445142 with TD occurrence, while also adding our unpublished genotype data. Overall, we found a significant association of the G allele with TD occurrence (p = 0.0001); however, much of the effect appeared to originate from the discovery dataset. Nonetheless, most study samples exhibit the same trend of association with TD for the G allele. Our findings encourage further genetic and molecular studies of HSPG2 in TD.
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spelling pubmed-61573252018-10-03 Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis Zai, Clement C. Lee, Frankie H. Tiwari, Arun K. Lu, Justin Y. de Luca, Vincenzo Maes, Miriam S. Herbert, Deanna Shahmirian, Anashe Cheema, Sheraz Y. Zai, Gwyneth C. Atukuri, Anupama Sherman, Michael Shaikh, Sajid A. Tampakeras, Maria Freeman, Natalie King, Nicole Müller, Daniel J. Greenbaum, Lior Lerer, Bernard Voineskos, Aristotle N. Potkin, Steven G. Lieberman, Jeffrey A. Meltzer, Herbert Y. Remington, Gary Kennedy, James L. Front Pharmacol Pharmacology Tardive dyskinesia (TD) is a movement disorder that may occur after extended use of antipsychotic medications. The etiopathophysiology is unclear; however, genetic factors play an important role. The Perlecan (HSPG2) gene was found to be significantly associated with TD in Japanese schizophrenia patients, and this association was subsequently replicated by an independent research group. To add to the evidence for this gene in TD, we conducted a meta-analysis specific to the relationship of HSPG2 rs2445142 with TD occurrence, while also adding our unpublished genotype data. Overall, we found a significant association of the G allele with TD occurrence (p = 0.0001); however, much of the effect appeared to originate from the discovery dataset. Nonetheless, most study samples exhibit the same trend of association with TD for the G allele. Our findings encourage further genetic and molecular studies of HSPG2 in TD. Frontiers Media S.A. 2018-09-18 /pmc/articles/PMC6157325/ /pubmed/30283332 http://dx.doi.org/10.3389/fphar.2018.00974 Text en Copyright © 2018 Zai, Lee, Tiwari, Lu, de Luca, Maes, Herbert, Shahmirian, Cheema, Zai, Atukuri, Sherman, Shaikh, Tampakeras, Freeman, King, Müller, Greenbaum, Lerer, Voineskos, Potkin, Lieberman, Meltzer, Remington and Kennedy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zai, Clement C.
Lee, Frankie H.
Tiwari, Arun K.
Lu, Justin Y.
de Luca, Vincenzo
Maes, Miriam S.
Herbert, Deanna
Shahmirian, Anashe
Cheema, Sheraz Y.
Zai, Gwyneth C.
Atukuri, Anupama
Sherman, Michael
Shaikh, Sajid A.
Tampakeras, Maria
Freeman, Natalie
King, Nicole
Müller, Daniel J.
Greenbaum, Lior
Lerer, Bernard
Voineskos, Aristotle N.
Potkin, Steven G.
Lieberman, Jeffrey A.
Meltzer, Herbert Y.
Remington, Gary
Kennedy, James L.
Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis
title Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis
title_full Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis
title_fullStr Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis
title_full_unstemmed Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis
title_short Investigation of the HSPG2 Gene in Tardive Dyskinesia – New Data and Meta-Analysis
title_sort investigation of the hspg2 gene in tardive dyskinesia – new data and meta-analysis
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157325/
https://www.ncbi.nlm.nih.gov/pubmed/30283332
http://dx.doi.org/10.3389/fphar.2018.00974
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