Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis

Chemokine synergy-inducing molecules are emerging as regulating factors in cell migration. The alarmin HMGB1, in its reduced form, can complex with CXCL12 enhancing its activity on monocytes via the chemokine receptor CXCR4, while the form containing a disulfide bond, by binding to TLR2 or TLR4, ini...

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Detalles Bibliográficos
Autores principales: Cecchinato, Valentina, D'Agostino, Gianluca, Raeli, Lorenzo, Nerviani, Alessandra, Schiraldi, Milena, Danelon, Gabriela, Manzo, Antonio, Thelen, Marcus, Ciurea, Adrian, Bianchi, Marco E., Rubartelli, Anna, Pitzalis, Costantino, Uguccioni, Mariagrazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157448/
https://www.ncbi.nlm.nih.gov/pubmed/30283452
http://dx.doi.org/10.3389/fimmu.2018.02118

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