Individual islet respirometry reveals functional diversity within the islet population of mice and human donors

OBJECTIVE: Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin secretion, little is known regarding heterogeneity in mitochondrial function at the individual islet level. This is due in part to...

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Detalles Bibliográficos
Autores principales: Taddeo, Evan P., Stiles, Linsey, Sereda, Samuel, Ritou, Eleni, Wolf, Dane M., Abdullah, Muhamad, Swanson, Zachary, Wilhelm, Josh, Bellin, Melena, McDonald, Patrick, Caradonna, Kacey, Neilson, Andrew, Liesa, Marc, Shirihai, Orian S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157638/
https://www.ncbi.nlm.nih.gov/pubmed/30098928
http://dx.doi.org/10.1016/j.molmet.2018.07.003

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