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Population Pharmacokinetic/Pharmacodynamic Analysis of Nociceptive Pain Models Following an Oral Pregabalin Dose Administration to Healthy Subjects

A battery of pain models can be used in clinical trials to investigate the efficacy and to establish the concentration‐effect relationship of novel analgesics. This study quantified the pharmacokinetics (PK) of pregabalin after a single oral dose of 300 mg and the pharmacodynamics (PD) on the pain t...

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Detalles Bibliográficos
Autores principales:	van Esdonk, Michiel J., Lindeman, Ian, Okkerse, Pieter, de Kam, Marieke L., Groeneveld, Geert J., Stevens, Jasper
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157667/ https://www.ncbi.nlm.nih.gov/pubmed/30043517 http://dx.doi.org/10.1002/psp4.12318

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