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Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations

PAX5, one of nine members of the mammalian paired box (PAX) family of transcription factors, plays an important role in B cell development. Approximately one-third of individuals with pre-B acute lymphoblastic leukemia (ALL) acquire heterozygous inactivating mutations of PAX5 in malignant cells, and...

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Detalles Bibliográficos
Autores principales:	Hart, Matthew R., Anderson, Donovan J., Porter, Christopher C., Neff, Tobias, Levin, Michael, Horwitz, Marshall S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157899/ https://www.ncbi.nlm.nih.gov/pubmed/30216339 http://dx.doi.org/10.1371/journal.pgen.1007642

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