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The CCT chaperonin is a novel regulator of Ca(2+) signaling through modulation of Orai1 trafficking

Store-operated Ca(2+) entry (SOCE) encodes a range of cellular responses downstream of Ca(2+) influx through the SOCE channel Orai1. Orai1 recycles at the plasma membrane (PM), with ~40% of the total Orai1 pool residing at the PM at steady state. The mechanisms regulating Orai1 recycling remain poor...

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Detalles Bibliográficos
Autores principales:	Hodeify, Rawad, Nandakumar, Manjula, Own, Maryam, Courjaret, Raphael J., Graumann, Johannes, Hubrack, Satanay Z., Machaca, Khaled
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157965/ https://www.ncbi.nlm.nih.gov/pubmed/30263962 http://dx.doi.org/10.1126/sciadv.aau1935

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