Evaluating biological activity of compounds by transcription factor activity profiling

Assessing the biological activity of compounds is an essential objective of biomedical research. We show that one can infer the bioactivity of compounds by assessing the activity of transcription factors (TFs) that regulate gene expression. Using a multiplex reporter system, the FACTORIAL, we charac...

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Detalles Bibliográficos
Autores principales: Medvedev, Alexander, Moeser, Matt, Medvedeva, Liubov, Martsen, Elena, Granick, Alexander, Raines, Lydia, Zeng, Ming, Makarov, Sergei, Houck, Keith A., Makarov, Sergei S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157966/
https://www.ncbi.nlm.nih.gov/pubmed/30263952
http://dx.doi.org/10.1126/sciadv.aar4666

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