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The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge

Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number of cases, targeted therapies have provided better prognosis. However, one specific subtype remai...

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Autores principales: Temian, Daiana Cosmina, Pop, Laura Ancuta, Irimie, Alexandra Iulia, Berindan-Neagoe, Ioana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Breast Cancer Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158152/
https://www.ncbi.nlm.nih.gov/pubmed/30275851
http://dx.doi.org/10.4048/jbc.2018.21.e41
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author Temian, Daiana Cosmina
Pop, Laura Ancuta
Irimie, Alexandra Iulia
Berindan-Neagoe, Ioana
author_facet Temian, Daiana Cosmina
Pop, Laura Ancuta
Irimie, Alexandra Iulia
Berindan-Neagoe, Ioana
author_sort Temian, Daiana Cosmina
collection PubMed
description Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number of cases, targeted therapies have provided better prognosis. However, one specific subtype remains elusive to targeted therapies–the triple-negative breast cancer. This immunohistochemically defined subtype is resistant to both endocrine and targeted therapies, leading to its poor prognosis. A field that is of great promise in current cancer research is epigenetics. By studying the epigenetic mechanisms underlying tumorigenesis–DNA methylation, histone modifications, and noncoding RNAs–advances in cancer treatment, diagnosis, and prevention are possible. This review aims to synthesize the epigenetic discoveries that have been made related to the triple-negative breast cancer.
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spelling pubmed-61581522018-10-01 The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge Temian, Daiana Cosmina Pop, Laura Ancuta Irimie, Alexandra Iulia Berindan-Neagoe, Ioana J Breast Cancer Review Article Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number of cases, targeted therapies have provided better prognosis. However, one specific subtype remains elusive to targeted therapies–the triple-negative breast cancer. This immunohistochemically defined subtype is resistant to both endocrine and targeted therapies, leading to its poor prognosis. A field that is of great promise in current cancer research is epigenetics. By studying the epigenetic mechanisms underlying tumorigenesis–DNA methylation, histone modifications, and noncoding RNAs–advances in cancer treatment, diagnosis, and prevention are possible. This review aims to synthesize the epigenetic discoveries that have been made related to the triple-negative breast cancer. Korean Breast Cancer Society 2018-09 2018-09-20 /pmc/articles/PMC6158152/ /pubmed/30275851 http://dx.doi.org/10.4048/jbc.2018.21.e41 Text en © 2018 Korean Breast Cancer Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Temian, Daiana Cosmina
Pop, Laura Ancuta
Irimie, Alexandra Iulia
Berindan-Neagoe, Ioana
The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
title The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
title_full The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
title_fullStr The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
title_full_unstemmed The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
title_short The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
title_sort epigenetics of triple-negative and basal-like breast cancer: current knowledge
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158152/
https://www.ncbi.nlm.nih.gov/pubmed/30275851
http://dx.doi.org/10.4048/jbc.2018.21.e41
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