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The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge
Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number of cases, targeted therapies have provided better prognosis. However, one specific subtype remai...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Breast Cancer Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158152/ https://www.ncbi.nlm.nih.gov/pubmed/30275851 http://dx.doi.org/10.4048/jbc.2018.21.e41 |
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author | Temian, Daiana Cosmina Pop, Laura Ancuta Irimie, Alexandra Iulia Berindan-Neagoe, Ioana |
author_facet | Temian, Daiana Cosmina Pop, Laura Ancuta Irimie, Alexandra Iulia Berindan-Neagoe, Ioana |
author_sort | Temian, Daiana Cosmina |
collection | PubMed |
description | Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number of cases, targeted therapies have provided better prognosis. However, one specific subtype remains elusive to targeted therapies–the triple-negative breast cancer. This immunohistochemically defined subtype is resistant to both endocrine and targeted therapies, leading to its poor prognosis. A field that is of great promise in current cancer research is epigenetics. By studying the epigenetic mechanisms underlying tumorigenesis–DNA methylation, histone modifications, and noncoding RNAs–advances in cancer treatment, diagnosis, and prevention are possible. This review aims to synthesize the epigenetic discoveries that have been made related to the triple-negative breast cancer. |
format | Online Article Text |
id | pubmed-6158152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Breast Cancer Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-61581522018-10-01 The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge Temian, Daiana Cosmina Pop, Laura Ancuta Irimie, Alexandra Iulia Berindan-Neagoe, Ioana J Breast Cancer Review Article Breast cancer has the highest incidence among all malignancies diagnosed in women. Therapies have significantly improved over the years due to extensive molecular and clinical research; in a large number of cases, targeted therapies have provided better prognosis. However, one specific subtype remains elusive to targeted therapies–the triple-negative breast cancer. This immunohistochemically defined subtype is resistant to both endocrine and targeted therapies, leading to its poor prognosis. A field that is of great promise in current cancer research is epigenetics. By studying the epigenetic mechanisms underlying tumorigenesis–DNA methylation, histone modifications, and noncoding RNAs–advances in cancer treatment, diagnosis, and prevention are possible. This review aims to synthesize the epigenetic discoveries that have been made related to the triple-negative breast cancer. Korean Breast Cancer Society 2018-09 2018-09-20 /pmc/articles/PMC6158152/ /pubmed/30275851 http://dx.doi.org/10.4048/jbc.2018.21.e41 Text en © 2018 Korean Breast Cancer Society http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Temian, Daiana Cosmina Pop, Laura Ancuta Irimie, Alexandra Iulia Berindan-Neagoe, Ioana The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge |
title | The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge |
title_full | The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge |
title_fullStr | The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge |
title_full_unstemmed | The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge |
title_short | The Epigenetics of Triple-Negative and Basal-Like Breast Cancer: Current Knowledge |
title_sort | epigenetics of triple-negative and basal-like breast cancer: current knowledge |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158152/ https://www.ncbi.nlm.nih.gov/pubmed/30275851 http://dx.doi.org/10.4048/jbc.2018.21.e41 |
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