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Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume
The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158214/ https://www.ncbi.nlm.nih.gov/pubmed/30258056 http://dx.doi.org/10.1038/s41467-018-06234-w |
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| author | Vojinovic, Dina Adams, Hieab H. Jian, Xueqiu Yang, Qiong Smith, Albert Vernon Bis, Joshua C. Teumer, Alexander Scholz, Markus Armstrong, Nicola J. Hofer, Edith Saba, Yasaman Luciano, Michelle Bernard, Manon Trompet, Stella Yang, Jingyun Gillespie, Nathan A. van der Lee, Sven J. Neumann, Alexander Ahmad, Shahzad Andreassen, Ole A. Ames, David Amin, Najaf Arfanakis, Konstantinos Bastin, Mark E. Becker, Diane M. Beiser, Alexa S. Beyer, Frauke Brodaty, Henry Bryan, R. Nick Bülow, Robin Dale, Anders M. De Jager, Philip L. Deary, Ian J. DeCarli, Charles Fleischman, Debra A. Gottesman, Rebecca F. van der Grond, Jeroen Gudnason, Vilmundur Harris, Tamara B. Homuth, Georg Knopman, David S. Kwok, John B. Lewis, Cora E. Li, Shuo Loeffler, Markus Lopez, Oscar L. Maillard, Pauline El Marroun, Hanan Mather, Karen A. Mosley, Thomas H. Muetzel, Ryan L. Nauck, Matthias Nyquist, Paul A. Panizzon, Matthew S. Pausova, Zdenka Psaty, Bruce M. Rice, Ken Rotter, Jerome I. Royle, Natalie Satizabal, Claudia L. Schmidt, Reinhold Schofield, Peter R. Schreiner, Pamela J. Sidney, Stephen Stott, David J. Thalamuthu, Anbupalam Uitterlinden, Andre G. Valdés Hernández, Maria C. Vernooij, Meike W. Wen, Wei White, Tonya Witte, A. Veronica Wittfeld, Katharina Wright, Margaret J. Yanek, Lisa R. Tiemeier, Henning Kremen, William S. Bennett, David A. Jukema, J. Wouter Paus, Tomas Wardlaw, Joanna M. Schmidt, Helena Sachdev, Perminder S. Villringer, Arno Grabe, Hans Jörgen Longstreth, W T van Duijn, Cornelia M. Launer, Lenore J. Seshadri, Sudha Ikram, M Arfan Fornage, Myriam |
| author_facet | Vojinovic, Dina Adams, Hieab H. Jian, Xueqiu Yang, Qiong Smith, Albert Vernon Bis, Joshua C. Teumer, Alexander Scholz, Markus Armstrong, Nicola J. Hofer, Edith Saba, Yasaman Luciano, Michelle Bernard, Manon Trompet, Stella Yang, Jingyun Gillespie, Nathan A. van der Lee, Sven J. Neumann, Alexander Ahmad, Shahzad Andreassen, Ole A. Ames, David Amin, Najaf Arfanakis, Konstantinos Bastin, Mark E. Becker, Diane M. Beiser, Alexa S. Beyer, Frauke Brodaty, Henry Bryan, R. Nick Bülow, Robin Dale, Anders M. De Jager, Philip L. Deary, Ian J. DeCarli, Charles Fleischman, Debra A. Gottesman, Rebecca F. van der Grond, Jeroen Gudnason, Vilmundur Harris, Tamara B. Homuth, Georg Knopman, David S. Kwok, John B. Lewis, Cora E. Li, Shuo Loeffler, Markus Lopez, Oscar L. Maillard, Pauline El Marroun, Hanan Mather, Karen A. Mosley, Thomas H. Muetzel, Ryan L. Nauck, Matthias Nyquist, Paul A. Panizzon, Matthew S. Pausova, Zdenka Psaty, Bruce M. Rice, Ken Rotter, Jerome I. Royle, Natalie Satizabal, Claudia L. Schmidt, Reinhold Schofield, Peter R. Schreiner, Pamela J. Sidney, Stephen Stott, David J. Thalamuthu, Anbupalam Uitterlinden, Andre G. Valdés Hernández, Maria C. Vernooij, Meike W. Wen, Wei White, Tonya Witte, A. Veronica Wittfeld, Katharina Wright, Margaret J. Yanek, Lisa R. Tiemeier, Henning Kremen, William S. Bennett, David A. Jukema, J. Wouter Paus, Tomas Wardlaw, Joanna M. Schmidt, Helena Sachdev, Perminder S. Villringer, Arno Grabe, Hans Jörgen Longstreth, W T van Duijn, Cornelia M. Launer, Lenore J. Seshadri, Sudha Ikram, M Arfan Fornage, Myriam |
| author_sort | Vojinovic, Dina |
| collection | PubMed |
| description | The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρ(genetic) = −0.59, p-value = 3.14 × 10(−6)), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology. |
| format | Online Article Text |
| id | pubmed-6158214 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-61582142018-10-01 Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume Vojinovic, Dina Adams, Hieab H. Jian, Xueqiu Yang, Qiong Smith, Albert Vernon Bis, Joshua C. Teumer, Alexander Scholz, Markus Armstrong, Nicola J. Hofer, Edith Saba, Yasaman Luciano, Michelle Bernard, Manon Trompet, Stella Yang, Jingyun Gillespie, Nathan A. van der Lee, Sven J. Neumann, Alexander Ahmad, Shahzad Andreassen, Ole A. Ames, David Amin, Najaf Arfanakis, Konstantinos Bastin, Mark E. Becker, Diane M. Beiser, Alexa S. Beyer, Frauke Brodaty, Henry Bryan, R. Nick Bülow, Robin Dale, Anders M. De Jager, Philip L. Deary, Ian J. DeCarli, Charles Fleischman, Debra A. Gottesman, Rebecca F. van der Grond, Jeroen Gudnason, Vilmundur Harris, Tamara B. Homuth, Georg Knopman, David S. Kwok, John B. Lewis, Cora E. Li, Shuo Loeffler, Markus Lopez, Oscar L. Maillard, Pauline El Marroun, Hanan Mather, Karen A. Mosley, Thomas H. Muetzel, Ryan L. Nauck, Matthias Nyquist, Paul A. Panizzon, Matthew S. Pausova, Zdenka Psaty, Bruce M. Rice, Ken Rotter, Jerome I. Royle, Natalie Satizabal, Claudia L. Schmidt, Reinhold Schofield, Peter R. Schreiner, Pamela J. Sidney, Stephen Stott, David J. Thalamuthu, Anbupalam Uitterlinden, Andre G. Valdés Hernández, Maria C. Vernooij, Meike W. Wen, Wei White, Tonya Witte, A. Veronica Wittfeld, Katharina Wright, Margaret J. Yanek, Lisa R. Tiemeier, Henning Kremen, William S. Bennett, David A. Jukema, J. Wouter Paus, Tomas Wardlaw, Joanna M. Schmidt, Helena Sachdev, Perminder S. Villringer, Arno Grabe, Hans Jörgen Longstreth, W T van Duijn, Cornelia M. Launer, Lenore J. Seshadri, Sudha Ikram, M Arfan Fornage, Myriam Nat Commun Article The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρ(genetic) = −0.59, p-value = 3.14 × 10(−6)), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology. Nature Publishing Group UK 2018-09-26 /pmc/articles/PMC6158214/ /pubmed/30258056 http://dx.doi.org/10.1038/s41467-018-06234-w Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Vojinovic, Dina Adams, Hieab H. Jian, Xueqiu Yang, Qiong Smith, Albert Vernon Bis, Joshua C. Teumer, Alexander Scholz, Markus Armstrong, Nicola J. Hofer, Edith Saba, Yasaman Luciano, Michelle Bernard, Manon Trompet, Stella Yang, Jingyun Gillespie, Nathan A. van der Lee, Sven J. Neumann, Alexander Ahmad, Shahzad Andreassen, Ole A. Ames, David Amin, Najaf Arfanakis, Konstantinos Bastin, Mark E. Becker, Diane M. Beiser, Alexa S. Beyer, Frauke Brodaty, Henry Bryan, R. Nick Bülow, Robin Dale, Anders M. De Jager, Philip L. Deary, Ian J. DeCarli, Charles Fleischman, Debra A. Gottesman, Rebecca F. van der Grond, Jeroen Gudnason, Vilmundur Harris, Tamara B. Homuth, Georg Knopman, David S. Kwok, John B. Lewis, Cora E. Li, Shuo Loeffler, Markus Lopez, Oscar L. Maillard, Pauline El Marroun, Hanan Mather, Karen A. Mosley, Thomas H. Muetzel, Ryan L. Nauck, Matthias Nyquist, Paul A. Panizzon, Matthew S. Pausova, Zdenka Psaty, Bruce M. Rice, Ken Rotter, Jerome I. Royle, Natalie Satizabal, Claudia L. Schmidt, Reinhold Schofield, Peter R. Schreiner, Pamela J. Sidney, Stephen Stott, David J. Thalamuthu, Anbupalam Uitterlinden, Andre G. Valdés Hernández, Maria C. Vernooij, Meike W. Wen, Wei White, Tonya Witte, A. Veronica Wittfeld, Katharina Wright, Margaret J. Yanek, Lisa R. Tiemeier, Henning Kremen, William S. Bennett, David A. Jukema, J. Wouter Paus, Tomas Wardlaw, Joanna M. Schmidt, Helena Sachdev, Perminder S. Villringer, Arno Grabe, Hans Jörgen Longstreth, W T van Duijn, Cornelia M. Launer, Lenore J. Seshadri, Sudha Ikram, M Arfan Fornage, Myriam Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume |
| title | Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume |
| title_full | Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume |
| title_fullStr | Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume |
| title_full_unstemmed | Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume |
| title_short | Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume |
| title_sort | genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158214/ https://www.ncbi.nlm.nih.gov/pubmed/30258056 http://dx.doi.org/10.1038/s41467-018-06234-w |
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