Cargando…
Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways
DNA damaging therapies can spur the formation of therapy-related cancers, due to mis-repair of lesions they create in non-cancerous cells. This risk may be amplified in patients with impaired DNA damage responses. We disabled key DNA damage response pathways using genetic and pharmacological approac...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158240/ https://www.ncbi.nlm.nih.gov/pubmed/30258062 http://dx.doi.org/10.1038/s41598-018-32517-9 |