Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers

There are considerable challenges in directly targeting the mutant p53 protein, given the large heterogeneity of p53 mutations in the clinic. An alternative approach is to exploit the altered fitness of cells imposed by loss-of-wild-type p53. Here we identify niclosamide through a HTS screen for com...

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Detalles Bibliográficos
Autores principales: Kumar, R., Coronel, L., Somalanka, B., Raju, A., Aning, O. A., An, O., Ho, Y. S., Chen, S., Mak, S. Y., Hor, P. Y., Yang, H., Lakshmanan, M., Itoh, H., Tan, S. Y., Lim, Y. K., Wong, A. P. C., Chew, S. H., Huynh, T. H., Goh, B. C., Lim, C. Y., Tergaonkar, V., Cheok, C. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158291/
https://www.ncbi.nlm.nih.gov/pubmed/30258081
http://dx.doi.org/10.1038/s41467-018-05805-1

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