Anti-glucocorticoid-induced Tumor Necrosis Factor–Related Protein (GITR) Therapy Overcomes Radiation-Induced Treg Immunosuppression and Drives Abscopal Effects

Despite the potential to cure metastatic disease, immunotherapy on its own often fails outright or early on due to tumor immune evasion. To address this obstacle, we investigated combinations of anti-GITR, anti-PD1 and radiation therapy (XRT) in our previously developed anti-PD1 resistant 344SQ non-...

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Detalles Bibliográficos
Autores principales: Schoenhals, Jonathan E., Cushman, Taylor R., Barsoumian, Hampartsoum B., Li, Ailin, Cadena, Alexandra P., Niknam, Sharareh, Younes, Ahmed I., Caetano, Mauricio da Silva, Cortez, Maria Angelica, Welsh, James W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158365/
https://www.ncbi.nlm.nih.gov/pubmed/30294332
http://dx.doi.org/10.3389/fimmu.2018.02170

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