Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study

Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34(+) cell transplantation has been s...

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Detalles Bibliográficos
Autores principales: Cerar, Andraz, Zemljic, Gregor, Frljak, Sabina, Jaklic, Martina, Poglajen, Gregor, Sever, Matjaz, Cukjati, Marko, Vrtovec, Bojan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158552/
https://www.ncbi.nlm.nih.gov/pubmed/29974792
http://dx.doi.org/10.1177/0963689718779349
Descripción
Sumario:Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34(+) cell transplantation has been shown to increase myocardial perfusion and function in patients with non-ischemic heart failure. In our first-in-man case study, we investigated the feasibility, safety and clinical effect of transendocardial CD34(+) cell therapy in a patient with noncompaction cardiomyopathy.

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