Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study

Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34(+) cell transplantation has been s...

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Autores principales: Cerar, Andraz, Zemljic, Gregor, Frljak, Sabina, Jaklic, Martina, Poglajen, Gregor, Sever, Matjaz, Cukjati, Marko, Vrtovec, Bojan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158552/
https://www.ncbi.nlm.nih.gov/pubmed/29974792
http://dx.doi.org/10.1177/0963689718779349
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author Cerar, Andraz
Zemljic, Gregor
Frljak, Sabina
Jaklic, Martina
Poglajen, Gregor
Sever, Matjaz
Cukjati, Marko
Vrtovec, Bojan
author_facet Cerar, Andraz
Zemljic, Gregor
Frljak, Sabina
Jaklic, Martina
Poglajen, Gregor
Sever, Matjaz
Cukjati, Marko
Vrtovec, Bojan
author_sort Cerar, Andraz
collection PubMed
description Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34(+) cell transplantation has been shown to increase myocardial perfusion and function in patients with non-ischemic heart failure. In our first-in-man case study, we investigated the feasibility, safety and clinical effect of transendocardial CD34(+) cell therapy in a patient with noncompaction cardiomyopathy.
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spelling pubmed-61585522018-10-01 Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study Cerar, Andraz Zemljic, Gregor Frljak, Sabina Jaklic, Martina Poglajen, Gregor Sever, Matjaz Cukjati, Marko Vrtovec, Bojan Cell Transplant Case Study Noncompaction cardiomyopathy is a rare congenital heart disorder characterized by an arrest of the myocardial compaction process. This results in the altered formation of coronary microvessels with a resulting decrease in myocardial perfusion. Transendocardial CD34(+) cell transplantation has been shown to increase myocardial perfusion and function in patients with non-ischemic heart failure. In our first-in-man case study, we investigated the feasibility, safety and clinical effect of transendocardial CD34(+) cell therapy in a patient with noncompaction cardiomyopathy. SAGE Publications 2018-07-05 2018-07 /pmc/articles/PMC6158552/ /pubmed/29974792 http://dx.doi.org/10.1177/0963689718779349 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Study
Cerar, Andraz
Zemljic, Gregor
Frljak, Sabina
Jaklic, Martina
Poglajen, Gregor
Sever, Matjaz
Cukjati, Marko
Vrtovec, Bojan
Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study
title Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study
title_full Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study
title_fullStr Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study
title_full_unstemmed Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study
title_short Transendocardial CD34(+) Cell Transplantation in Noncompaction Cardiomyopathy: First-in-Man Case Study
title_sort transendocardial cd34(+) cell transplantation in noncompaction cardiomyopathy: first-in-man case study
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158552/
https://www.ncbi.nlm.nih.gov/pubmed/29974792
http://dx.doi.org/10.1177/0963689718779349
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