Cargando…

IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors

The oncofetal IGF2 mRNA binding proteins (IGF2BPs) are upregulated in most cancers but their paralogue-specific roles in tumor cells remain poorly understood. In a panel of five cancer-derived cell lines, IGF2BP1 shows highly conserved oncogenic potential. Consistently, the deletion of IGF2BP1 impai...

Descripción completa

Detalles Bibliográficos
Autores principales:	Müller, Simon, Bley, Nadine, Glaß, Markus, Busch, Bianca, Rousseau, Vanessa, Misiak, Danny, Fuchs, Tommy, Lederer, Marcell, Hüttelmaier, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158595/ https://www.ncbi.nlm.nih.gov/pubmed/29660014 http://dx.doi.org/10.1093/nar/gky229

Ejemplares similares

IGF2BP1 promotes SRF-dependent transcription in cancer in a m(6)A- and miRNA-dependent manner
por: Müller, Simon, et al.
Publicado: (2019)

The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family
por: Busch, Bianca, et al.
Publicado: (2016)

Stress granules are dispensable for mRNA stabilization during cellular stress
por: Bley, Nadine, et al.
Publicado: (2015)

Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes
por: Minocha, Rashmi, et al.
Publicado: (2018)

Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
por: Mestre-Farràs, Neus, et al.
Publicado: (2022)

G3BP1 binds to guanine quadruplexes in mRNAs to modulate their stabilities
por: He, Xiaomei, et al.
Publicado: (2021)

G3BP1-linked mRNA partitioning supports selective protein synthesis in response to oxidative stress
por: Somasekharan, Syam Prakash, et al.
Publicado: (2020)

A RanBP2-type zinc finger protein functions in intron splicing in Arabidopsis mitochondria and is involved in the biogenesis of respiratory complex I
por: Bentolila, Stéphane, et al.
Publicado: (2021)

Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system
por: Angrand, Gaelle, et al.
Publicado: (2022)

The RNA binding protein Quaking represses splicing of the Fibronectin EDA exon and downregulates the interferon response
por: Liao, Kuo-Chieh, et al.
Publicado: (2021)

Methylated HNRNPK acts on RPS19 to regulate ALOX15 synthesis in erythropoiesis
por: Naarmann-de Vries, Isabel S, et al.
Publicado: (2021)

In vivo probing of nascent RNA structures reveals principles of cotranscriptional folding
por: Incarnato, Danny, et al.
Publicado: (2017)

PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2)
por: Landry-Voyer, Anne-Marie, et al.
Publicado: (2020)

In vivo analysis of influenza A mRNA secondary structures identifies critical regulatory motifs
por: Simon, Lisa Marie, et al.
Publicado: (2019)

Cutting in-line with iron: ribosomal function and non-oxidative RNA cleavage
por: Guth-Metzler, Rebecca, et al.
Publicado: (2020)

Positive-sense RNA viruses reveal the complexity and dynamics of the cellular and viral epitranscriptomes during infection
por: McIntyre, Will, et al.
Publicado: (2018)

Targeting alternative splicing by RNAi: from the differential impact on splice variants to triggering artificial pre-mRNA splicing
por: Fuchs, Armin, et al.
Publicado: (2021)

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
por: Olthof, Anouk M, et al.
Publicado: (2021)

mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1
por: Jia, Jian-Jun, et al.
Publicado: (2021)

IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression
por: Hagemann, Sven, et al.
Publicado: (2023)

A mechanism underlying position-specific regulation of alternative splicing
por: Hamid, Fursham M., et al.
Publicado: (2017)

A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression
por: Goyal, Ashish, et al.
Publicado: (2017)

Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism
por: Scott, Daniel D., et al.
Publicado: (2017)

The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells
por: Ouyang, Huiwu, et al.
Publicado: (2017)

The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria
por: Reinhard, Linda, et al.
Publicado: (2017)

Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
por: Bogorad, Andrew M., et al.
Publicado: (2017)

Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide
por: Tang, Leiming, et al.
Publicado: (2017)

Cdk5rap1-mediated 2-methylthio-N(6)-isopentenyladenosine modification is absent from nuclear-derived RNA species
por: Fakruddin, Md., et al.
Publicado: (2017)

The SMAD3 transcription factor binds complex RNA structures with high affinity
por: Dickey, Thayne H., et al.
Publicado: (2017)

An engineered RNA binding protein with improved splicing regulation
por: Hale, Melissa A, et al.
Publicado: (2018)

Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27(Kip1)
por: Roilo, Martina, et al.
Publicado: (2018)

Viewing pre-60S maturation at a minute’s timescale
por: Zisser, Gertrude, et al.
Publicado: (2018)

Combined roles of ATP and small hairpin RNA in the activation of RIG-I revealed by solution-based analysis
por: Shah, Neelam, et al.
Publicado: (2018)

Viral suppressors of RNAi employ a rapid screening mode to discriminate viral RNA from cellular small RNA
por: Fareh, Mohamed, et al.
Publicado: (2018)

Translational regulation by bacterial small RNAs via an unusual Hfq-dependent mechanism
por: Azam, Muhammad S, et al.
Publicado: (2018)

Contrasting silencing mechanisms of the same target mRNA by two regulatory RNAs in Escherichia coli
por: Lalaouna, David, et al.
Publicado: (2018)

Probing of RNA structures in a positive sense RNA virus reveals selection pressures for structural elements
por: Watters, Kyle E, et al.
Publicado: (2018)

RNA-binding specificity landscapes of designer pentatricopeptide repeat proteins elucidate principles of PPR–RNA interactions
por: Miranda, Rafael G, et al.
Publicado: (2018)

Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P
por: Mariotti, Marco, et al.
Publicado: (2017)

Polycytidylation of mitochondrial mRNAs in Chlamydomonas reinhardtii
por: Salinas-Giegé, Thalia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_kq6t9in2qt6c4pkn52q9t8amb1