Enzymatic synthesis of random sequences of RNA and RNA analogues by DNA polymerase theta mutants for the generation of aptamer libraries

Nucleic acid aptamers, especially RNA, exhibit valuable advantages compared to protein therapeutics in terms of size, affinity and specificity. However, the synthesis of libraries of large random RNAs is still difficult and expensive. The engineering of polymerases able to directly generate these li...

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Detalles Bibliográficos
Autores principales: Randrianjatovo-Gbalou, Irina, Rosario, Sandrine, Sismeiro, Odile, Varet, Hugo, Legendre, Rachel, Coppée, Jean-Yves, Huteau, Valérie, Pochet, Sylvie, Delarue, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158600/
https://www.ncbi.nlm.nih.gov/pubmed/29788485
http://dx.doi.org/10.1093/nar/gky413

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